The mammalian CYP1A1, CYP1A2, and CYP1B1 genes (encoding cytochromes P450 1A1,
1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR). The …

The phenomenon of P-450 induction has fascinated pharmacologists from times even before
P-450 was known to exist as such. Induction is a familiar story, a tale that has been told in …

A considerable body of research over the past fifteen years establishes that in laboratory
animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of …

Conventional biochemical and molecular techniques identified previously several genes
whose expression is regulated by the aryl hydrocarbon receptor (AHR). We sought to map the …

The science of toxicology is devoted, in large part, to understanding mechanisms of toxicity
so that we can more accurately assess the risk posed by exposure to xenobiotic agents and, …

The effect of route of administration on the ability of indole-3-carbinol (I3C), an anticarcinogen
present in cruciferous vegetables, to induce estradiol 2-hydroxylase (EH) in female rat …

The AH receptor (AHR) mediates toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as
well as induction of three cytochrome P450 enzymes and certain Phase II enzymes. In …

The aryl hydrocarbon receptor (AHR) participates in a wide range of critical cellular events
in response to endogenous signals or xenobiotic chemicals. Hence, it is important that AHR …

Biochemical and toxic effects of halogenated aromatic hydrocarbons such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
(TCDD) are mediated by the AH receptor, which functions as a ligand-…

Ah "nonresponsive" mice (prototype, DBA/2) show no significant increase in hepatic P1-450
(P450IA1) when treated with 3-methylcholanthrene or other nonhalogenated polycyclic …