Pregnancy decreases rat CYP1A2 activity and expression
AA Walker, L Dickmann, N Isoherranen - Drug metabolism and disposition, 2011 - ASPET
Pregnancy results in increased CYP3A- and CYP2D6-mediated clearance but decreases
the clearance of CYP1A2 probe drugs. The aim of this study was to determine whether the …
the clearance of CYP1A2 probe drugs. The aim of this study was to determine whether the …
Intravenous and oral alfentanil as in vivo probes for hepatic and first‐pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis
ED Kharasch, A Walker, C Hoffer… - Clinical Pharmacology …, 2004 - Wiley Online Library
Introduction Systemic clearance of intravenous (IV) alfentanil (ALF) is an in vivo probe for
hepatic cytochrome P450 (CYP) 3A activity, miosis is a surrogate for plasma ALF …
hepatic cytochrome P450 (CYP) 3A activity, miosis is a surrogate for plasma ALF …
Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with …
…, C Hoffer, D Whittington, A Walker… - The Journal of the …, 2009 - pubs.asahq.org
Background Methadone clearance is highly variable, and drug interactions are problematic.
Both have been attributed to CYP3A, but actual mechanisms are unknown. Drug …
Both have been attributed to CYP3A, but actual mechanisms are unknown. Drug …
Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P‐glycoprotein activities
ED Kharasch, PS Bedynek, A Walker… - Clinical …, 2008 - Wiley Online Library
Ritonavir diminishes methadone plasma concentrations, an effect attributed to CYP3A induction,
but the actual mechanisms are unknown. We determined short‐term (2‐day) and steady…
but the actual mechanisms are unknown. We determined short‐term (2‐day) and steady…
Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity
ED Kharasch, A Walker, D Whittington, C Hoffer… - Drug and alcohol …, 2009 - Elsevier
BACKGROUND: Methadone plasma concentrations are decreased by nelfinavir.
Methadone clearance and the drug interactions have been attributed to CYP3A4, but actual …
Methadone clearance and the drug interactions have been attributed to CYP3A4, but actual …
Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance
…, S Park, D Whittington, A Walker… - Clinical …, 2008 - Wiley Online Library
Ritonavir diminishes methadone plasma concentrations, an effect attributed to CYP3A
induction, but the actual mechanisms are unknown. We determined ritonavir effects on …
induction, but the actual mechanisms are unknown. We determined ritonavir effects on …
Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A)
…, PS Bedynek, C Hoffer, A Walker… - The Journal of the …, 2012 - pubs.asahq.org
Background Methadone disposition and pharmacodynamics are highly susceptible to
interactions with antiretroviral drugs. Methadone clearance and drug interactions have been …
interactions with antiretroviral drugs. Methadone clearance and drug interactions have been …
Evaluation of first‐pass cytochrome P4503A (CYP3A) and P‐glycoprotein activities using alfentanil and fexofenadine in combination
ED Kharasch, A Walker, C Hoffer… - The Journal of Clinical …, 2005 - Wiley Online Library
Cytochrome P4503A (CYP3A) and P‐glycoprotein (P‐gp) are major determinants of oral
bioavailability. Development of in vivo probe(s), for both CYP3A and P‐gp, which could be …
bioavailability. Development of in vivo probe(s), for both CYP3A and P‐gp, which could be …
Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first‐pass CYP3A activity
ED Kharasch, A Walker, C Hoffer… - The Journal of Clinical …, 2005 - Wiley Online Library
This investigation determined the ability of alfentanil miosis and single‐point concentrations
to detect various degrees of CYP3A inhibition. Results were compared with those for …
to detect various degrees of CYP3A inhibition. Results were compared with those for …
Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first‐pass cytochrome P4503A activity
ED Kharasch, C Hoffer, A Walker… - Clinical Pharmacology …, 2003 - Wiley Online Library
Background and Objectives Systemic clearance of the opioid alfentanil after intravenous
administration is an excellent in vivo probe for hepatic cytochrome P4503A (CYP3A) activity …
administration is an excellent in vivo probe for hepatic cytochrome P4503A (CYP3A) activity …