Antioxidant and α-glucosidase inhibitory phenolics isolated from highbush blueberry flowers
Blueberries have been extensively researched, but there are limited studies on other parts
of the plant. Here we report the first phytochemical examination of highbush blueberry (…
of the plant. Here we report the first phytochemical examination of highbush blueberry (…
Do we need to study metabolism and distribution in the eye: why, when, and are we there yet?
…, JL Dumouchel, VM Kramlinger, AL Cirello… - Journal of …, 2017 - Elsevier
The liver is known to be the principal site of drug metabolism. Depending on the route of
administration, especially in cases of topical and local delivery, evaluation of local drug …
administration, especially in cases of topical and local delivery, evaluation of local drug …
Ocular metabolism of levobunolol: historic and emerging metabolic pathways
…, JL Dumouchel, CE Dunne, C Saran, AL Cirello… - Drug Metabolism and …, 2016 - ASPET
Although ocular transport and delivery have been well studied, metabolism in the eye is not
well documented, even for clinically available medications such as levobunolol, a potent and …
well documented, even for clinically available medications such as levobunolol, a potent and …
In vitro ocular metabolism and bioactivation of ketoconazole in rat, rabbit and human
AL Cirello, JL Dumouchel, M Gunduz, CE Dunne… - Drug metabolism and …, 2017 - Elsevier
Oral ketoconazole is clinically administered for treatment of severe cases for fungal keratitis.
Pharmacodynamics and efficacy of oral and topical (ocular) ketoconazole have been …
Pharmacodynamics and efficacy of oral and topical (ocular) ketoconazole have been …
New perspectives on acyl glucuronide risk assessment in drug discovery: investigation of in vitro stability, in situ reactivity, and bioactivation
M Gunduz, UA Argikar, AL Cirello… - Drug Metabolism …, 2018 - ingentaconnect.com
Background: Acyl glucuronides of xenobiotics have been a subject of wide interest from the
pharmaceutical industry with respect to biochemical reactivity, hepatic disposition, and …
pharmaceutical industry with respect to biochemical reactivity, hepatic disposition, and …
Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl) pyrido [2, 3-e][1, 2, 4] triazolo [4, 3-a] pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy …
M Gunduz, AL Cirello, P Klimko… - Drug Metabolism …, 2017 - ingentaconnect.com
Background: 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazine (1)
is a small-molecule which demonstrated a sub-nM inhibitory potency toward the histamine …
is a small-molecule which demonstrated a sub-nM inhibitory potency toward the histamine …
Investigation of ocular bioactivation potential and the role of cytochrome P450 2D enzymes in rat
…, CE Dunne, VM Kramlinger, AL Cirello… - Drug Metabolism …, 2017 - ingentaconnect.com
Background: Timolol is clinically administered topically (ocular) to reduce intraocular pressure
and treat open-angle glaucoma. Ocular administration of timolol in low doses (0.5% w/v in …
and treat open-angle glaucoma. Ocular administration of timolol in low doses (0.5% w/v in …
[CITATION][C] In vitro investigation of catabolism and metabolism of antibody drug conjugates (ADCS)
M Gunduz, AL Cirello, JL Dumouchel, D Hainzl… - Drug Metabolism and …, 2018 - cir.nii.ac.jp
… Amanda L. Cirello Jennifer L. Dumouchel …
Phytochemicals from the roots of northern highbush blueberry (Vaccinium corymbosum)
A Cirello - 2013 - search.proquest.com
Growing evidence from many in vitro studies suggest that plants produce secondary metabolites
which may have potential physiological properties. The northern highbush blueberry (…
which may have potential physiological properties. The northern highbush blueberry (…
Novel miniaturized drug conjugate leverages HSP90-driven tumor accumulation to overcome PI3K inhibitor delivery challenges to solid tumors
S Perino, B Moreau, J Freda, A Cirello, BH White… - Molecular Cancer …, 2020 - AACR
The PI3K pathway is considered a master regulator for cancer due to its frequent activation,
making it an attractive target for pharmacologic intervention. While substantial efforts have …
making it an attractive target for pharmacologic intervention. While substantial efforts have …