Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes.
Its current stringent restriction to patients with critical metabolic lability is justified by the …

Impaired wound healing is a frequent and very severe problem in patients with diabetes
mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the …

Poly(butylcyanoacrylate) nanoparticles were produced by emulsion polymerisation and used
either uncoated or overcoated with polysorbate 80 (Tween® 80). [ 3 H]-dalargin bound to …

Islet transplantation is a feasible therapeutic alternative for metabolically labile patients with
type 1 diabetes. The primary therapeutic target is stable glycemic control and prevention of …

Lead optimization of a high‐throughput screening hit led to the rapid identification of
aminopyrimidine ZK 304709, a multitargeted CDK and VEGF‐R inhibitor that displayed a promising …

Despite enormous efforts, achieving a safe and efficacious concentration profile in the brain
remains one of the big challenges in central nervous system (CNS) drug discovery and …

The first successful isolation of cerebral microvessels from rat brain some 30 years ago
opened the way to the development of in vitro models of the blood-brain barrier (BBB), which …

Intestinal ATP binding cassette (ABC) transporters may affect the bioavailability and
effectiveness of orally administered drugs. Available studies on regional expression of intestinal …

The blood-brain barrier (BBB) remains one of the greatest challenges for the discovery and
development of treatments for CNS disorders, which to this day remains one of the riskiest …

The potential of enzyme inhibition of a drug is frequently quantified in terms of IC 50 values.
Although this is a suitable quantity for reversible inhibitors, concerns arise when dealing with …