User profiles for Andrzej T. Slominski

Andrzej Slominski

Professor of Dermatology, UAB
Verified email at uabmc.edu
Cited by 42556

[BOOK][B] Melatoninergic system in the skin

…, B Zbytek, RM Slominski, JD Steketee, AT Slominski… - 2012 - Springer
Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et al. …

Melatonin membrane receptors in peripheral tissues: distribution and functions

RM Slominski, RJ Reiter… - Molecular and cellular …, 2012 - Elsevier
Many of melatonin’s actions are mediated through interaction with the G-protein coupled
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or, …

[HTML][HTML] Melanoma, melanin, and melanogenesis: The Yin and Yang relationship

RM Slominski, T Sarna, PM Płonka, C Raman… - Frontiers in …, 2022 - frontiersin.org
Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet
radiation and other environmental stressors. It is produced by the enzymatic transformation …

Key role of CRF in the skin stress response system

AT Slominski, MA Zmijewski, B Zbytek… - Endocrine …, 2013 - academic.oup.com
The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

How UV light touches the brain and endocrine system through skin, and why

AT Slominski, MA Zmijewski, PM Plonka… - …, 2018 - academic.oup.com
The skin, a self-regulating protective barrier organ, is empowered with sensory and computing
capabilities to counteract the environmental stressors to maintain and restore disrupted …

[HTML][HTML] In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1

AT Slominski, TK Kim, HZ Shehabi, I Semak… - The FASEB …, 2012 - ncbi.nlm.nih.gov
We define previously unrecognized in vivo pathways of vitamin D 3 (D3) metabolism generating
novel D3-hydroxyderivatives different from 25-hydroxyvitamin D 3 [25 (OH) D3] and 1, …

[HTML][HTML] RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy-and 20, 23-dihydroxyvitamin D

AT Slominski, TK Kim, Y Takeda, Z Janjetovic… - The FASEB …, 2014 - ncbi.nlm.nih.gov
RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-hydroxyvitamin
D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3]. Chinese …

Novel activities of CYP11A1 and their potential physiological significance

AT Slominski, W Li, TK Kim, I Semak, J Wang… - The Journal of steroid …, 2015 - Elsevier
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol and …

[HTML][HTML] Melatonin: a cutaneous perspective on its production, metabolism, and functions

AT Slominski, R Hardeland, MA Zmijewski… - Journal of Investigative …, 2018 - Elsevier
Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …

Photobiology of vitamin D

MF Holick, AT Slominski - Feldman and Pike's Vitamin D, 2024 - Elsevier
Vitamin D is the sunshine vitamin. During exposure to sunlight, 7-dehydrocholesterol in the
skin absorbs ultraviolet B (UVB) radiation converting it to previtamin D3. Previtamin D3 being …