Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man
LB Goh, KJ Spears, D Yao, A Ayrton, P Morgan… - Biochemical …, 2002 - Elsevier
The epithelial canine and porcine kidney cell lines MDCK, MDCKII and LLC-PK1, respectively
are employed to establish recombinant models of drug transport. Endogenous drug …
are employed to establish recombinant models of drug transport. Endogenous drug …
Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers
W El-Sankary, GG Gibson, A Ayrton, N Plant - Drug Metabolism and …, 2001 - ASPET
Regulation of the CYP3A4 gene has been studied using an in vitro reporter gene assay. The
effect of 17 xenobiotics on ∼1 kilobase of the CYP3A4 proximal promoter, upstream of a …
effect of 17 xenobiotics on ∼1 kilobase of the CYP3A4 proximal promoter, upstream of a …
An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development
…, L Chen, M Taylor, I Baines, L Zhu, A Ayrton… - Chemico-biological …, 2011 - Elsevier
Metabolic bioactivation is widely considered an undesirable event and a likely prerequisite
step in the expression of drug-induced hepatotoxicity and hypersensitivity. Reducing …
step in the expression of drug-induced hepatotoxicity and hypersensitivity. Reducing …
Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2
…, CJ Ward, LB Goh, CR Wolf, P Morgan, A Ayrton… - Biochemical …, 2005 - Elsevier
The transcellular transport of many compounds, which cannot readily cross the lipid bilayer,
is mediated by drug uptake and efflux transporters. Human OATP1B1 and MRP2 have been …
is mediated by drug uptake and efflux transporters. Human OATP1B1 and MRP2 have been …
[PDF][PDF] If the KI is defined by the free energy of binding to P-gp, what kinetic parameters define the IC50 for the MDCKII-hMDR1 confluent cell monolayer?
AA Lumen, P Acharya, JW Polli, A Ayrton… - Drug Metabolism and …, 2009 - researchgate.net
From previous fits of drug transport kinetics across confluent MDCKII-hMDR1 cell monolayers,
we found that a drug’s binding constant to P-gp was significantly smaller than its IC50 …
we found that a drug’s binding constant to P-gp was significantly smaller than its IC50 …
[CITATION][C] Characterization of metabolites by ion-trap LC-MSn
…, DM MURPHY, R SOZIO, A AYRTON - American …, 2000 - pascal-francis.inist.fr
… M 3 ; SOZIO, R 3 ; AYRTON, A 3 ; SCHAEFER, W. H 4 …
[BOOK][B] An investigation of host cell effects on the xenobiotic induction of cytochrome P450 3A
KE Swales - 2002 - search.proquest.com
… detection system to be set up in the UK For this I thank my industrial supervisors Andy Ayrton
and Steve Hood. Andy, I thank for setting up the project and watching over me for the first …
and Steve Hood. Andy, I thank for setting up the project and watching over me for the first …
[CITATION][C] Kinetic identification of membrane transporters that assist P-gp mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII …
P Acharya, MP O'Connor, JW Polli, A Ayrton… - Drug Metabolism and …, 2007 - ASPET
A robust screen for compound interaction with P-gp requires a cell line expressing P-gp and
a probe-substrate which is transported solely by P-gp and passive permeability. While this is …
a probe-substrate which is transported solely by P-gp and passive permeability. While this is …
Keith Stirling: An introduction to his life and examination of his music
BA Ayrton - 2011 - ses.library.usyd.edu.au
This study introduces the life and examines the music of Australian jazz trumpeter Keith
Stirling (1938-2003). The paper discusses the importance and position of Stirling in the jazz …
Stirling (1938-2003). The paper discusses the importance and position of Stirling in the jazz …
[HTML][HTML] Center for International Maritime Security
B Wall, N Ayrton - cimsec.org
… By Brandon Wall and Nicholas Ayrton … Nicholas Ayrton is a US Navy veteran and current
undergraduate student at … Andy on A Modest Proposal for Improving Shipyard Production and …
undergraduate student at … Andy on A Modest Proposal for Improving Shipyard Production and …