[HTML][HTML] Strategic focus on 3R principles reveals major reductions in the use of animals in pharmaceutical toxicity testing
E Törnqvist, A Annas, B Granath, E Jalkesten… - PloS one, 2014 - journals.plos.org
The principles of the 3Rs, Replacement, Reduction and Refinement, are being increasingly
incorporated into legislations, guidelines and practice of animal experiments in order to …
incorporated into legislations, guidelines and practice of animal experiments in order to …
[HTML][HTML] In situ mass spectrometry imaging and ex vivo characterization of renal crystalline deposits induced in multiple preclinical drug toxicology studies
…, RJA Goodwin, E Basmaci, I Gustafsson, A Annas… - 2012 - journals.plos.org
Drug toxicity observed in animal studies during drug development accounts for the
discontinuation of many drug candidates, with the kidney being a major site of tissue damage. …
discontinuation of many drug candidates, with the kidney being a major site of tissue damage. …
Effects of lactic acid bacteria on the uptake and distribution of the food mutagen Trp-P-2 in mice
KM Orrhage, A Annas, CE Nord… - Scandinavian journal …, 2002 - Taylor & Francis
Background : Lactic acid bacteria have been reported to have antimutagenic and anticarcinogenic
properties in vivo and in vitro. Lactobacillus acidophilus and Bifidobacterium longum …
properties in vivo and in vitro. Lactobacillus acidophilus and Bifidobacterium longum …
Long-term retention of neurotoxic β-carbolines in brain neuromelanin
A Ö: stergren, A Annas, K Skog, NG Lindquist… - Journal of neural …, 2004 - Springer
β-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
and are metabolized to mitochondrial toxicants. Humans are continuously …
and are metabolized to mitochondrial toxicants. Humans are continuously …
Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine
JD Lindh, A Annas, L Meurling, ML Dahl… - European journal of …, 2003 - Springer
Objective To study the influence of CYP3A4 inhibition by ketoconazole on the disposition of
venlafaxine in individuals with different CYP2D6 pheno- and genotypes. Methods In an open …
venlafaxine in individuals with different CYP2D6 pheno- and genotypes. Methods In an open …
[HTML][HTML] Characteristics and outcomes of e-cigarette exposure incidents reported to 10 European Poison Centers: a retrospective data analysis
…, R Kastanje, I de Vries, L Scholtens, A Annas… - Tobacco induced …, 2017 - Springer
Background The use of e-cigarettes has increased during the past few years. Exposure to e-cigarette
liquids, whether intentional or accidental, may lead to adverse events our aim was …
liquids, whether intentional or accidental, may lead to adverse events our aim was …
Evaluation of benzo (a) pyrene-induced DNA damage in human endothelial cells using alkaline single cell gel electrophoresis
A Annas, E Brittebo, B Hellman - Mutation Research/Genetic Toxicology …, 2000 - Elsevier
The alkaline version of the ‘comet assay’ was used to evaluate DNA damage in human umbilical
vein endothelial cells (HUVEC) exposed to 0.1, 1.0, or 10μM benzo(a)pyrene for 90min. …
vein endothelial cells (HUVEC) exposed to 0.1, 1.0, or 10μM benzo(a)pyrene for 90min. …
Potential pharmacobezoar formation of large size extended-release tablets and their dissolution–an in vitro study
…, S Ullah, G Panagiotidis, TS Petersen, A Annas - Clinical …, 2019 - Taylor & Francis
Objective: Extended release (ER) tablets/capsules in massive ingestion overdoses are prone
to form pharmacobezoars potentially increasing the risk of late-appearing toxic effects and …
to form pharmacobezoars potentially increasing the risk of late-appearing toxic effects and …
[HTML][HTML] Records from the Swedish poisons information centre as a means for surveillance of occupational accidents and incidents with chemicals
We present a retrospective analysis of records on occupational accidents from the Swedish
Poisons Information Centre. The aim was to explore these data as a means for surveillance …
Poisons Information Centre. The aim was to explore these data as a means for surveillance …
Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and …
A Annas, AL Granberg, EB Brittebo - Toxicology and applied pharmacology, 2000 - Elsevier
In the present study, 7-ethoxyresorufin O-deethylase (EROD), 7,12-dimethylbenz[a]anthracene
(DMBA)-hydroxylase, and covalent binding of 3 H-labeled 3-amino-1,4-dimethyl-5H-…
(DMBA)-hydroxylase, and covalent binding of 3 H-labeled 3-amino-1,4-dimethyl-5H-…