Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes

A Äbelö, TB Andersson, M Antonsson, AK Naudot… - Drug Metabolism and …, 2000 - ASPET
This study demonstrates the stereoselective metabolism of the optical isomers of omeprazole
in human liver microsomes. The intrinsic clearance (CL int ) of the formation of the hydroxy …

Theoretical assumptions of sustainable work places development in rural areas.

V Pilipavičius - 2012 - cabidigitallibrary.org
Work places development in rural areas is one of the most important tasks for the European
Union and Lithuania in implementation of agricultural and rural development policies and its …

Worked and unworked bone from the Viljandi castle of the Livonian Order (13th–16th centuries)

A Haak, E Rannamäe, H Luik, L Maldre - Lietuvos archeologija, 2012 - ceeol.com
… Data from tooth eruption partly confirms that – out of seven analysed mandibles three …
Three broken crossbow nuts and some working debris of producing these items has been …

Typological Features of Balys Dvarionas' Cinema Music in the Movie „Until It's Too Late”

D Milius - LOGOS-A Journal of Religion, Philosophy …, 2020 - ceeol.com
… Bandoma plačiau pažvelgti, kaip naudoti muzikos tipai kuria (arba nekuria) papildomas …
excite, “Riešutų duo na” (Bread of the Nuts) has become the most watched comedy, “Skrydis per …

Jura novit curia principo taikymas tarptautiniame komerciniame arbitraže (Application of the Jura Novit Curia Principle in International Commercial Arbitration)

R Daujotas, B Kozubovska - Periodical journal" VU mokslo darbai …, 2013 - papers.ssrn.com
Lithuanian Abstract: Straipsnyje analizuojamas jura novit curia principo taikymas tarptautiniame
komerciniame arbitraže. Arbitraže nėra nusistovėjusios jura novit curia principo taikymo …

[BOOK][B] CYP2C19 and brain development: implications for susceptibility to anxiety in a transgenic mouse model

A Persson - 2013 - search.proquest.com
The cytochrome P450-2C19 enzyme is involved in the metabolism of about 10% of all drugs
used today and displays high genetic polymorphism, causing absent, decreased or …

Progress in ADME Prediction Using GRID‐Molecular Interaction Fields

I Zamora, M Ridderström, AL Ungell… - … Applications in Drug …, 2005 - Wiley Online Library
There are several aspects regarding the absorption, distribution, metabolism and excretion (ADME)
properties of new chemical entities (NCE) that are relevant during the drug discovery …

[HTML][HTML] Long-term flow through human intestinal organoids with the gut organoid flow chip (GOFlowChip)

B Sidar, BR Jenkins, S Huang, JR Spence, ST Walk… - Lab on a Chip, 2019 - pubs.rsc.org
… Layers were sealed through gaskets between each layer and compressing the assembled
layers using nuts and bolts (McMaster Carr; 316 stainless steel, M3 × 0.3 mm thread, 10 mm …

Regional Impact Models: Problems of Application in Lithuania

V PUKELIENË, N ÈEPAITIENË - 2004 - ceeol.com
… would require significant modification in order to analyze policy changes. Because of the
signifi… From the perspective of the EU regional policy Lithuania is considered a single NUTS II …

Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery

Z Yan, GW Caldwell - Current topics in medicinal chemistry, 2001 - ingentaconnect.com
To reduce the high attrition rates of NCEs in preclinical and clinical development uncovering
pharmacokinetics, toxicokinetics, drug metabolism, and drug-drug interactions early in drug …