To demonstrate the benefits of RNA-Seq over microarray in transcriptome profiling, both
RNA-Seq and microarray analyses were performed on RNA samples from a human T cell …

Fig. 1 Laser capture microdissection from Nissl-stained sections (10 µm in thickness) of
adult rat large and small DRG neurons. Red arrows indicate DRG neurons to be captured (top …

Background Inflammation and oxidative stress play critical roles in patients with chronic
obstructive pulmonary disease (COPD). Mitochondrial oxidative stress might be involved in …

Many aspects of physiology and behavior are temporally organized into daily 24 hr rhythms,
driven by an endogenous circadian clock. Studies in eukaryotes have identified a network of …

Laser capture microdissection in combination with microarrays allows for the expression
analysis of thousands of genes in selected cells. Here we describe single-cell gene expression …

Background MicroRNAs (MiRNAs) are short non-coding RNAs that control protein expression
through various mechanisms. Their altered expression has been shown to be associated …

We describe, for the first time, the generation of a viral DNA chip for simultaneous expression
measurements of nearly all known open reading frames (ORFs) in the largest member of …

The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating
IL-17–producing CD4 + Th17 T cells, which are essential in host defense and may play …

Human cytomegalovirus (HCMV) infection alters the expression of many cellular genes,
including IFN-stimulated genes (ISGs) [Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T. & Shenk, T…

Toxicogenomics technology defines toxicity gene expression signatures for early predictions
and hypotheses generation for mechanistic studies, which are important approaches for …