User profiles for Arul Jayaraman

Arul Jayaraman

Professor of Chemical Engineering, Texas A&M University
Verified email at tamu.edu
Cited by 11558

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

…, TK Wood, A Jayaraman - Proceedings of the …, 2010 - National Acad Sciences
Interkingdom signaling is established in the gastrointestinal tract in that human hormones
trigger responses in bacteria; here, we show that the corollary is true, that a specific bacterial …

[HTML][HTML] Indole is an inter-species biofilm signal mediated by SdiA

J Lee, A Jayaraman, TK Wood - BMC microbiology, 2007 - Springer
Background As a stationary phase signal, indole is secreted in large quantities into rich medium
by Escherichia coli and has been shown to control several genes (eg, astD, tnaB, gabT), …

Bacterial quorum sensing: signals, circuits, and implications for biofilms and disease

A Jayaraman, TK Wood - Annu. Rev. Biomed. Eng., 2008 - annualreviews.org
Communication between bacteria, belonging to the same species or to different species, is
mediated through different chemical signals that are synthesized and secreted by bacteria. …

[PDF][PDF] Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages

…, DH Sherr, ML Yarmush, RC Alaniz, A Jayaraman… - Cell reports, 2018 - cell.com
The gut microbiota plays a significant role in the progression of fatty liver disease; however,
the mediators and their mechanisms remain to be elucidated. Comparing metabolite profile …

Differential Effects of Epinephrine, Norepinephrine, and Indole on Escherichia coli O157:H7 Chemotaxis, Colonization, and Gene Expression

…, J Lee, M Hegde, TK Wood, A Jayaraman - Infection and …, 2007 - Am Soc Microbiol
During infection in the gastrointestinal tract, enterohemorrhagic Escherichia coli (EHEC)
O157:H7 is exposed to a wide range of signaling molecules, including the eukaryotic hormones …

Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities

…, G Sridharan, K Lee, LA Davidson, A Jayaraman… - Molecular …, 2014 - ASPET
The tryptophan metabolites indole, indole-3-acetate, and tryptamine were identified in mouse
cecal extracts and fecal pellets by mass spectrometry. The aryl hydrocarbon receptor (AHR…

[HTML][HTML] Prediction and quantification of bioactive microbiota metabolites in the mouse gut

…, RC Alaniz, K Lee, A Jayaraman - Nature …, 2014 - nature.com
Metabolites produced by the intestinal microbiota are potentially important physiological
modulators. Here we present a metabolomics strategy that models microbiota metabolism as a …

Enterohemorrhagic Escherichia coli Biofilms Are Inhibited by 7-Hydroxyindole and Stimulated by Isatin

J Lee, T Bansal, A Jayaraman… - Applied and …, 2007 - Am Soc Microbiol
Since indole is present at up to 500 μM in the stationary phase and is an interspecies biofilm
signal (J. Lee, A. Jayaraman, and TK Wood, BMC Microbiol. 7:42, 2007), we investigated …

A high-throughput microfluidic real-time gene expression living cell array

KR King, S Wang, D Irimia, A Jayaraman, M Toner… - Lab on a Chip, 2007 - pubs.rsc.org
The dynamics of gene expression are fundamental to the coordination of cellular responses.
Measurement of temporal gene expression patterns is currently limited to destructive low-…

[HTML][HTML] Synthetic quorum-sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device

…, M Hegde, J Kim, X Wang, A Jayaraman… - Nature …, 2012 - nature.com
To utilize biofilms for chemical transformations in biorefineries they need to be controlled
and replaced. Previously, we engineered the global regulator Hha and cyclic diguanylate-…