Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of …
…, H Kawakami, T Inoue, S Liehner, A Saito… - Drug metabolism and …, 2012 - ASPET
The purpose of the present study was to determine the absolute protein expression levels of
multiple drug-metabolizing enzymes and transporters in 17 human liver biopsies, and to …
multiple drug-metabolizing enzymes and transporters in 17 human liver biopsies, and to …
Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans
N Ishiguro, K Maeda, W Kishimoto, A Saito… - Drug metabolism and …, 2006 - ASPET
Telmisartan, a nonpeptide angiotensin II receptor antagonist, is selectively distributed to liver.
In the present study, we have characterized the contribution of organic anion transporting …
In the present study, we have characterized the contribution of organic anion transporting …
Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human …
…, H Kawakami, T Inoue, S Liehner, A Saito… - Drug Metabolism and …, 2012 - ASPET
The levels of metabolizing enzymes and transporters expressed in hepatocytes are decisive
factors for hepatobiliary disposition of most drugs. Induction via nuclear receptor activation …
factors for hepatobiliary disposition of most drugs. Induction via nuclear receptor activation …
Effects of Efflux Transporter Genes on Susceptibility of Escherichia coli to Tigecycline (GAR-936)
T Hirata, A Saito, K Nishino, N Tamura… - Antimicrobial agents …, 2004 - Am Soc Microbiol
The activity of tigecycline, 9-(t-butylglycylamido)-minocycline, against Escherichia coli KAM3
(acrB) strains harboring plasmids encoding various tetracycline-specific efflux transporter …
(acrB) strains harboring plasmids encoding various tetracycline-specific efflux transporter …
Anaerobic nitrogen-fixing consortia consisting of clostridia isolated from gramineous plants
…, T Miyamoto, M You, A Saito, M Saito… - Applied and …, 2004 - Am Soc Microbiol
We report here the existence of anaerobic nitrogen-fixing consortia (ANFICOs) consisting of
N 2 -fixing clostridia and diverse nondiazotrophic bacteria in nonleguminous plants; we …
N 2 -fixing clostridia and diverse nondiazotrophic bacteria in nonleguminous plants; we …
A concise total synthesis of (+)-neopeltolide
(Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide
has been synthesized based on the strategic application of olefin metathesis …
has been synthesized based on the strategic application of olefin metathesis …
[HTML][HTML] Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson's disease: Retrograde degeneration observed by tract-profile …
…, K Kamagata, T Hatano, A Okuzumi, A Saito… - Parkinsonism & related …, 2018 - Elsevier
Introduction Parkinson's disease (PD) is marked by the degeneration of dopaminergic neurons
in the nigrostriatal pathway (NSP). We aimed to identify the microstructural changes in …
in the nigrostriatal pathway (NSP). We aimed to identify the microstructural changes in …
[HTML][HTML] Free-water imaging in white and gray matter in Parkinson's disease
This study aimed to discriminate between neuroinflammation and neuronal degeneration in
the white matter (WM) and gray matter (GM) of patients with Parkinson’s disease (PD) using …
the white matter (WM) and gray matter (GM) of patients with Parkinson’s disease (PD) using …
[HTML][HTML] Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus
…, M Nakajima, K Kamagata, K Tsuruta, A Saito… - NeuroImage: Clinical, 2017 - Elsevier
The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt
surgery, but prediction of treatment outcome is not established. We investigated changes …
surgery, but prediction of treatment outcome is not established. We investigated changes …
Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the …
N Ishiguro, K Maeda, A Saito, W Kishimoto… - Drug metabolism and …, 2008 - ASPET
In the hepatic uptake of organic anions, organic anion transporting polypeptide (OATP) 1B1
is believed to be mainly involved. We have constructed a set of double-transfected cells …
is believed to be mainly involved. We have constructed a set of double-transfected cells …