Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of …

…, H Kawakami, T Inoue, S Liehner, A Saito… - Drug metabolism and …, 2012 - ASPET
The purpose of the present study was to determine the absolute protein expression levels of
multiple drug-metabolizing enzymes and transporters in 17 human liver biopsies, and to …

Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans

N Ishiguro, K Maeda, W Kishimoto, A Saito… - Drug metabolism and …, 2006 - ASPET
Telmisartan, a nonpeptide angiotensin II receptor antagonist, is selectively distributed to liver.
In the present study, we have characterized the contribution of organic anion transporting …

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human …

…, H Kawakami, T Inoue, S Liehner, A Saito… - Drug Metabolism and …, 2012 - ASPET
The levels of metabolizing enzymes and transporters expressed in hepatocytes are decisive
factors for hepatobiliary disposition of most drugs. Induction via nuclear receptor activation …

Effects of Efflux Transporter Genes on Susceptibility of Escherichia coli to Tigecycline (GAR-936)

T Hirata, A Saito, K Nishino, N Tamura… - Antimicrobial agents …, 2004 - Am Soc Microbiol
The activity of tigecycline, 9-(t-butylglycylamido)-minocycline, against Escherichia coli KAM3
(acrB) strains harboring plasmids encoding various tetracycline-specific efflux transporter …

Anaerobic nitrogen-fixing consortia consisting of clostridia isolated from gramineous plants

…, T Miyamoto, M You, A Saito, M Saito… - Applied and …, 2004 - Am Soc Microbiol
We report here the existence of anaerobic nitrogen-fixing consortia (ANFICOs) consisting of
N 2 -fixing clostridia and diverse nondiazotrophic bacteria in nonleguminous plants; we …

A concise total synthesis of (+)-neopeltolide

H Fuwa, A Saito, M Sasaki - … Chemie-International Edition, 2010 - tohoku.elsevierpure.com
(Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide
has been synthesized based on the strategic application of olefin metathesis …

[HTML][HTML] Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson's disease: Retrograde degeneration observed by tract-profile …

…, K Kamagata, T Hatano, A Okuzumi, A Saito… - Parkinsonism & related …, 2018 - Elsevier
Introduction Parkinson's disease (PD) is marked by the degeneration of dopaminergic neurons
in the nigrostriatal pathway (NSP). We aimed to identify the microstructural changes in …

[HTML][HTML] Free-water imaging in white and gray matter in Parkinson's disease

C Andica, K Kamagata, T Hatano, A Saito, W Uchida… - Cells, 2019 - mdpi.com
This study aimed to discriminate between neuroinflammation and neuronal degeneration in
the white matter (WM) and gray matter (GM) of patients with Parkinson’s disease (PD) using …

[HTML][HTML] Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus

…, M Nakajima, K Kamagata, K Tsuruta, A Saito… - NeuroImage: Clinical, 2017 - Elsevier
The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt
surgery, but prediction of treatment outcome is not established. We investigated changes …

Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the …

N Ishiguro, K Maeda, A Saito, W Kishimoto… - Drug metabolism and …, 2008 - ASPET
In the hepatic uptake of organic anions, organic anion transporting polypeptide (OATP) 1B1
is believed to be mainly involved. We have constructed a set of double-transfected cells …