User profiles for Ayman O.S. El-Kadi

Ayman El-Kadi

University of Alberta
Verified email at ualberta.ca
Cited by 7902

Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases

BNM Zordoky, AOS El-Kadi - Pharmacology & therapeutics, 2010 - Elsevier
Cardiovascular diseases (CVDs) remain the leading cause of death in the developed
countries. Taking into account the mounting evidence about the role of cytochrome P450 (CYP) …

Cytochrome P450 enzymes: central players in cardiovascular health and disease

RH Elbekai, AOS El-Kadi - Pharmacology & therapeutics, 2006 - Elsevier
Cardiovascular disease (CVD) is a human health crisis that remains the leading cause of
death worldwide. The cytochrome P450 (CYP) class of enzymes are key metabolizers of both …

Role of NF-κB in the regulation of cytochrome P450 enzymes

BNM Zordoky, AOS El-Kadi - Current drug metabolism, 2009 - ingentaconnect.com
Nuclear factor kappa B (NF-κB) is an important transcription factor that regulates a wide
spectrum of genes including cytochrome P450 (CYP), the most important family of drug …

The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases

HM Korashy, AOS El-Kadi - Drug metabolism reviews, 2006 - Taylor & Francis
Numerous experimental and epidemiological studies have demonstrated that polycyclic
aromatic hydrocarbons (PAHs), which are major constituents of cigarette tobacco tar, are …

Empagliflozin blunts worsening cardiac dysfunction associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3) inflammasome activation in …

…, JWS Jahng, D Vos, N Parajuli, AOS El-Kadi… - Circulation: Heart …, 2020 - Am Heart Assoc
Background: Although empagliflozin was shown to profoundly reduce cardiovascular
events in diabetic patients and blunt the decline in cardiac function in nondiabetic mice with …

[HTML][HTML] Camel milk triggers apoptotic signaling pathways in human hepatoma HepG2 and breast cancer MCF7 cell lines through transcriptional mechanism

…, ZH Maayah, AR Abd-Allah, AOS El-Kadi… - BioMed Research …, 2012 - hindawi.com
Few published studies have reported the use of crude camel milk in the treatment of stomach
infections, tuberculosis and cancer. Yet, little research was conducted on the effect of …

The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes

…, HM Korashy, AOS El-Kadi - Current drug metabolism, 2004 - ingentaconnect.com
Cirrhosis is the end stage of many forms of liver pathologies including hepatitis. The liver is
known for its vital role in the processing of xenobiotics, including drugs and toxic compounds. …

The duality of arsenic metabolism: impact on human health

MA El-Ghiaty, AOS El-Kadi - Annual review of pharmacology …, 2023 - annualreviews.org
Arsenic is a naturally occurring hazardous element that is environmentally ubiquitous in
various chemical forms. Upon exposure, the human body initiates an elimination pathway of …

H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart

BNM Zordoky, AOS El-Kadi - Journal of pharmacological and toxicological …, 2007 - Elsevier
INTRODUCTION: Recent studies demonstrated that cultured primary cardiomyocytes are a
valuable tool for studying the metabolic capacity of the heart. However, a major limitation for …

The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine

A Alshamsan, S Hamdy, J Samuel, AOS El-Kadi… - Biomaterials, 2010 - Elsevier
Persistent activation of signal transducer and activator of transcription 3 (STAT3) has been
shown to impart several oncogenic features in many solid and blood tumors. In this study, we …