DMSO is a clear odorless liquid, inexpensively produced as a by-product of the paper industry.
It is widely available in the USA as a solvent but its medical use is currently restricted by …

Background Dupilumab is a fully human anti–interleukin-4 receptor α monoclonal antibody
that blocks both interleukin-4 and interleukin-13 signaling. We assessed its efficacy and …

In order to explain the potent antihypertensive activity of the modestly active (ICso= 3.2 mM)
dihydropyrimidine calcium channel blocker 5, we carried out drug metabolism studies in the …

Background Dupilumab is a fully human anti–interleukin-4 receptor α monoclonal antibody
that blocks both interleukin-4 and interleukin-13 signaling. Its effectiveness in reducing oral …

Introduction Calcium channel blocking agents are widely used in the management of
angina pectoris and hypertension. 2 Within this class of cardiovascular agents, the …

Background & Aims Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory
disease with no approved treatment in the United States. Dupilumab, a VelocImmune-derived …

Background Type 2 inflammation is common in numerous atopic/allergic diseases and can
be identified by elevated biomarker levels. Dupilumab, a fully human monoclonal antibody, …

Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a type 2‐mediated
inflammatory disease associated with significant clinical, social, and economic burdens and …

The relationship of apparent steady-state serum concentrations of amiodarone and its
metabolite, desethylamiodarone, to therapeutic and toxic effects was assessed in 127 patients …

The oral bioavailability of two HMG‐CoA reductase inhibitors, pravastatin and lovastatin,
was investigated in this randomized, two‐way crossover study. Twenty healthy men were …