Bile acid synthesis is a major pathway for cholesterol disposal and thus represents a
potential therapeutic target pathway for the treatment of hypercholesterolemia. Recently, the …

Bile acids are essential for the solubilization and transport of dietary lipids and are the major
products of cholesterol catabolism. Results presented here show that bile acids are …

The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and subsequent
gene targeting studies in mice provided strong evidence that LXR plays a central role in …

In healthy individuals, acute changes in cholesterol intake produce modest changes in plasma
cholesterol levels. A striking exception occurs in sitosterolemia, an autosomal recessive …

The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that
are bound and activated by oxysterols. These receptors serve as sterol sensors to regulate …

Growth/differentiation factor 15 (GDF15), also known as MIC-1, is a distant member of the
transforming growth factor-β (TGF-β) superfamily and has been implicated in various biological …

Sterol regulatory element-binding protein-1c (SREBP-1c) enhances transcription of genes
encoding enzymes of unsaturated fatty acid biosynthesis in liver. SREBP-1c mRNA is known …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C)
by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for …

E2F-1, the first gene product identified among a family of E2F transcription factors, is thought
to play a critical role in G 1 /S progression of the cell cycle. Transcriptional activities of E2F …

The in vivo role of the nuclear receptor SHP in feedback regulation of bile acid synthesis was
examined. Loss of SHP in mice caused abnormal accumulation and increased synthesis of …