Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

…, G Antoni, CA Mathis, B Långström - Annals of Neurology …, 2004 - Wiley Online Library
This report describes the first human study of a novel amyloid‐imaging positron emission
tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with diagnosed …

PET imaging of amyloid deposition in patients with mild cognitive impairment

…, G Hagman, A Wall, A Ringheim, B Långström… - Neurobiology of …, 2008 - Elsevier
It is of great clinical value to identify subjects at a high risk of developing AD. We previously
found that the amyloid positron emission tomography (PET) tracer PIB showed a robust …

Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy

…, H Fischer, A Pissiota, B Långström… - Archives of general …, 2002 - jamanetwork.com
Background Neurofunctional changes underlying effective antianxiety treatments are
incompletely characterized. This study explored the effects of citalopram and cognitive-behavioral …

Two-year follow-up of amyloid deposition in patients with Alzheimer's disease

…, I Savitcheva, A Wall, A Ringheim, B Långström… - Brain, 2006 - academic.oup.com
Beta amyloid is one of the major histopathological hallmarks of Alzheimer's disease. We
recently reported in vivo imaging of amyloid in 16 Alzheimer patients, using the PET ligand N-…

The use of PET in Alzheimer disease

…, JO Rinne, A Kadir, B Långström - Nature Reviews …, 2010 - nature.com
In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years. …

Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B …

…, A Wall, H Engler, B Långström… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD)
brain tissue. It is therefore of great interest to develop a PET tracer for visualizing …

Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study

…, H Fischer, A Pissiota, B Långström… - American journal of …, 2001 - Am Psychiatric Assoc
OBJECTIVE: The central nervous system representation of social phobia (social anxiety
disorder) is largely unknown. The aim of this study was to examine brain activity during symptom …

Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(β-11C) DOPA and PET

…, T Lundberg, M Bergström, P Hartvig, B Långström - Biological …, 1999 - Elsevier
Background: The aim of the present study was to investigate dopamine synthesis in the brain
of drug-free schizophrenic patients, not only in the striatum but also in extrastriatal areas …

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

…, M Palner, BR Kornum, O Rahman, B Långström… - Drug metabolism and …, 2009 - ASPET
Species differences occur in the brain concentrations of drugs, but the reasons for these
differences are not yet apparent. This study was designed to compare brain uptake of three …

Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development

M Bergström, A Grahnen, B Långström - European journal of clinical …, 2003 - Springer
The realisation that new chemical entities under development as drug candidates fail in
three of four cases in clinical trials, together with increased costs and increased demands of …