Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
…, G Antoni, CA Mathis, B Långström - Annals of Neurology …, 2004 - Wiley Online Library
This report describes the first human study of a novel amyloid‐imaging positron emission
tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with diagnosed …
tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with diagnosed …
PET imaging of amyloid deposition in patients with mild cognitive impairment
…, G Hagman, A Wall, A Ringheim, B Långström… - Neurobiology of …, 2008 - Elsevier
It is of great clinical value to identify subjects at a high risk of developing AD. We previously
found that the amyloid positron emission tomography (PET) tracer PIB showed a robust …
found that the amyloid positron emission tomography (PET) tracer PIB showed a robust …
Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy
…, H Fischer, A Pissiota, B Långström… - Archives of general …, 2002 - jamanetwork.com
Background Neurofunctional changes underlying effective antianxiety treatments are
incompletely characterized. This study explored the effects of citalopram and cognitive-behavioral …
incompletely characterized. This study explored the effects of citalopram and cognitive-behavioral …
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
…, I Savitcheva, A Wall, A Ringheim, B Långström… - Brain, 2006 - academic.oup.com
Beta amyloid is one of the major histopathological hallmarks of Alzheimer's disease. We
recently reported in vivo imaging of amyloid in 16 Alzheimer patients, using the PET ligand N-…
recently reported in vivo imaging of amyloid in 16 Alzheimer patients, using the PET ligand N-…
The use of PET in Alzheimer disease
…, JO Rinne, A Kadir, B Långström - Nature Reviews …, 2010 - nature.com
In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years. …
disease pathology most probably precedes the onset of cognitive symptoms by many years. …
Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B …
…, A Wall, H Engler, B Långström… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD)
brain tissue. It is therefore of great interest to develop a PET tracer for visualizing …
brain tissue. It is therefore of great interest to develop a PET tracer for visualizing …
Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study
…, H Fischer, A Pissiota, B Långström… - American journal of …, 2001 - Am Psychiatric Assoc
OBJECTIVE: The central nervous system representation of social phobia (social anxiety
disorder) is largely unknown. The aim of this study was to examine brain activity during symptom …
disorder) is largely unknown. The aim of this study was to examine brain activity during symptom …
Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(β-11C) DOPA and PET
…, T Lundberg, M Bergström, P Hartvig, B Långström - Biological …, 1999 - Elsevier
Background: The aim of the present study was to investigate dopamine synthesis in the brain
of drug-free schizophrenic patients, not only in the striatum but also in extrastriatal areas …
of drug-free schizophrenic patients, not only in the striatum but also in extrastriatal areas …
Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport
Species differences occur in the brain concentrations of drugs, but the reasons for these
differences are not yet apparent. This study was designed to compare brain uptake of three …
differences are not yet apparent. This study was designed to compare brain uptake of three …
Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development
M Bergström, A Grahnen, B Långström - European journal of clinical …, 2003 - Springer
The realisation that new chemical entities under development as drug candidates fail in
three of four cases in clinical trials, together with increased costs and increased demands of …
three of four cases in clinical trials, together with increased costs and increased demands of …