The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

This study reports on a novel, high-throughput assay, designed to predict passive, transcellular
permeability in early drug discovery. The assay is carried out in 96-well microtiterplates …

Alkylamides (alkamides) from Echinacea modulate tumor necrosis factor α mRNA expression
in human monocytes/macrophages via the cannabinoid type 2 (CB 2 ) receptor (Gertsch, J.…

PAMPA, log P OCT , and Caco‐2 are useful tools in drug discovery for the prediction of oral
absorption, brain penetration and for the development of structure‐permeability relationships…

Cell-free permeation systems are gaining interest in drug discovery and development as
tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages …

Evidence supporting the action of passive diffusion and carrier-mediated (CM) transport in
drug bioavailability and disposition is discussed to refute the recently proposed theory that …

Recently, it has been proposed that drug permeation is essentially carrier-mediated only and
that passive lipoidal diffusion is negligible. This opposes the prevailing hypothesis of drug …

Water solubility is an important molecular property for successful drug development as it is a
key factor governing drug access to biological membranes. There have been a number of …

This study describes a method for mining and modeling binding data obtained from a large
panel of targets (in vitro safety pharmacology) to distinguish differences between …

The aim of this study was to understand which parameters are responsible for the selective
modulation of compounds solubility in simulated intestinal fluids. The solubility of 25 …