Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers

F Waldmeier, U Glaenzel, B Wirz, L Oberer… - Drug metabolism and …, 2007 - ASPET
Aliskiren (2(S),4(S),5(S),7(S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamid
hemifumarate) is the first in a …

The outstanding metabolic stability of a 14C‐labeled β‐nonapeptide in rats – in vitro and in vivo pharmacokinetic studies

H Wiegand, B Wirz, A Schweitzer… - … & drug disposition, 2002 - Wiley Online Library
In vitro studies: In CaCo‐2 cell monolayers the β‐nonapeptide H(β‐HAla‐β‐HLys‐β‐HPhe)
3 ‐OH·4HCl (1), 14 C‐labeled on both C atoms of the CH 2 –CO moiety of the central β‐…

ADME Investigations of Unnatural Peptides: Distribution of a 14C‐Labeled β3‐Octaarginine in Rats

HM Weiss, B Wirz, A Schweitzer… - Chemistry & …, 2007 - Wiley Online Library
The highly positively charged, cell‐penetrating β 3 ‐octaarginine has been prepared with a
radioactive label by acetylation at the N‐terminus with a doubly 14 C‐labeled acetyl group ( …

Pharmacokinetic Investigation of a 14C‐Labelled β3 Tetrapeptide in Rats

H Wiegand, B Wirz, A Schweitzer, G Gross… - Chemistry & …, 2004 - Wiley Online Library
The solid‐phase synthesis and an ADME investigation with albino and pigmented male rats
of the doubly 14 C‐labelled β/α‐tetrapeptide derivative Ac‐β 3 hTyr‐(D)Trp‐β 3 hLys‐β 3 …

Measurement of clomipramine, N-desmethyl-clomipramine, imipramine, and dehydroimipramine in biological fluids by selective ion monitoring, and pharmacokinetics …

JP Dubois, W Küng, W Theobald, B Wirz - Clinical chemistry, 1976 - academic.oup.com
To quantitatively determine tricyclic antidepressant agents, we used a combined gas
chromatograph/mass spectrometer system, and deuterium-labeled internal standards. Recovery …

Metabolism and disposition of the oral absorption enhancer 14C-radiolabeled 8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC) in healthy …

HP Gschwind, U Glaenzel, F Waldmeier, B Wirz… - European journal of …, 2012 - Elsevier
8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC), a compound lacking
pharmacological activity enhances the absorption of salmon calcitonin, when co-administered. …

Pitfalls and limitations in the practical use of Förster's theory of resonance energy transfer

…, GD Scholes, G Schweitzer, B Valeur, J Wirz - Photochemical & …, 2008 - Springer
… Scholes,*d Gerd Schweitzer,b Bernard Valeur*e and Jakob Wirz*f … E-mail: bernard.valeur@cnam.fr
fDepartment of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel …

In Vitro versus In Vivo Comparison of Endotracheal Tube Airflow Resistance1-4

PE Wright, JJ Marini, GR Bernard - Am Rev Respir Dis, 1989 - atsjournals.org
… We employed a modification of the Von Neergard and Wirz method (12) using an
airwaycatheter with multiple side holes in order to calculate patient and artificial lung pulmonary re…

Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: prospective multicentre study

M Egger, B Hirschel, P Francioli, P Sudre, M Wirz… - Bmj, 1997 - bmj.com
Objectives: To examine trends in disease progression and survival among patients enrolled
in the Swiss HIV cohort study during 1988–96 and to assess the influence of new …

The Role of Airflow Resistance in Patients with the Adult Respiratory Distress Syndrome1-4

PE Wright, GR Bernard - 1988 - atsjournals.org
… Using a modification of the method of von Neergard and Wirz (14), lung resistance (average
of inspiratory and expiratory resistance) was measured at midtidal volume by dividing …