Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1 (–/–) mice
…, JA Hunt, N Gorman, BW Walton-Strong… - Drug metabolism and …, 2007 - ASPET
CYP2E1 is widely accepted as the sole form of cytochrome P450 responsible for alcohol-mediated
increases in acetaminophen (APAP) hepatotoxicity. However, we previously found …
increases in acetaminophen (APAP) hepatotoxicity. However, we previously found …
Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity
KK Wolf, SG Wood, JA Hunt, BW Walton-Strong… - Drug metabolism and …, 2005 - ASPET
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing
enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and …
enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and …
DARK DESCENDEN) TS; NEO-GOTHIC
SE Maier - Neo-Gothic Narratives: Illusory Allusions from the Past, 2020 - books.google.com
… The reader ponders Frankenstein's possible secret; in Frankenstein, Peter Brooks sees “an …
It is important to remember Walton's strong affinity for Frankenstein; in Frankenstein, Walton …
It is important to remember Walton's strong affinity for Frankenstein; in Frankenstein, Walton …
Bacterial-and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity
JF Maddox, CJ Amuzie, M Li, SW Newport… - Journal of Toxicology …, 2009 - Taylor & Francis
Acetaminophen (APAP)-induced hepatotoxicity accounts for nearly half of acute liver failure
cases in the United States. The doses that produce hepatotoxicity vary considerably and …
cases in the United States. The doses that produce hepatotoxicity vary considerably and …
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
Y Jiang, X Fan, Y Wang, H Tan, P Chen, H Zeng… - Chemico-biological …, 2015 - Elsevier
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. Schisandra fructus is widely-used traditional Chinese medicine which possesses hepato…
failure. Schisandra fructus is widely-used traditional Chinese medicine which possesses hepato…
[BOOK][B] Modulation of CYPs: Effect on acetaminophen hepatotoxicity
KK Wolf - 2006 - search.proquest.com
… Seth Brooks for all of his insight and helpful suggestions on real time RT-PCR. Dr. Herb …
Cytosolic fractions were extracted with an equal volume of 10% (w/v) TCA, while 5% (w/v) TCA …
Cytosolic fractions were extracted with an equal volume of 10% (w/v) TCA, while 5% (w/v) TCA …
[HTML][HTML] Hepatic, extrahepatic and extracellular vesicle cytochrome p450 2e1 in alcohol and acetaminophen-mediated adverse interactions and potential treatment …
Alcohol and several therapeutic drugs, including acetaminophen, are metabolized by
cytochrome P450 2E1 (CYP2E1) into toxic compounds. At low levels, these compounds are not …
cytochrome P450 2E1 (CYP2E1) into toxic compounds. At low levels, these compounds are not …
Oxidative and non-oxidative metabolomics of ethanol
RJ Dinis-Oliveira - Current drug metabolism, 2016 - ingentaconnect.com
Background: It is well known that ethanol can cause significant morbidity and mortality, and
much of the related toxic effects can be explained by its metabolic profile. Objective: This …
much of the related toxic effects can be explained by its metabolic profile. Objective: This …
Oxidative and Non-Oxidative Metabolomics of Ethanol
RJD Oliveira - 2016 - repositorio-aberto.up.pt
Background: It is well known that ethanol can cause significant morbidity and mortality, and
much of the related toxic effects can be explained by its metabolic profile. Objective: This …
much of the related toxic effects can be explained by its metabolic profile. Objective: This …
[BOOK][B] A QUALITATIVE ANALYTIC STUDY OF THE IMAGE OF ORGANIZED RELIGION IN PRIME TIME TELEVISION DRAMA.
PH KECKLEY JR - 1974 - search.proquest.com
… To Professors Keith Brooks and Donald Cegala for their encouragement and participation …
In 1902, the famed psychologist William James penned The Varieties of Religious Experience …
In 1902, the famed psychologist William James penned The Varieties of Religious Experience …