The authors tested 239 frequently used drugs and other compounds for their potential to
inhibit the drug‐metabolizing enzyme, aldehyde oxidase, in human liver cytosol. A sensitive, …

… clinical dose of ziprasidone (160 mg/day) under steady-state conditions, introduction of
ketoconazole at 400 mg/day produced a 39% increase in exposure at the estimated time of C …

… However, in vitro a number of other compounds such as potassium ferricyanide, cytochrome
c , and dichlorophenolindophenol can replace oxygen in its role as an electron acceptor [ 15…

… 10 μM leupeptin at 4C and homogenized at 12,000 rpm for 1–2 min, using a Ystral X10/25
homogenizer at 4C. The resulting homogenate was then heated at 55–57C for 10 min on a …

The activity of hepatic aldehyde oxidase from rabbit, guinea pig, rat, marmoset, dog, baboon
and man was investigated in vitro with charged and uncharged N-heterocyclic substrates: K …

Publisher Summary This chapter discusses the biological distribution and substrate-inhibitor
specificity of molybdenum hydroxylases. Aldehyde oxidase and xanthine oxidase are …

… Both N-oxides can be reduced back to nicotine by tissue reductases such as cytochrome
P450, NADPH-cytochrome (c) reductase and xanthine oxidase and/or gut flora [9] and can thus …

… Initial oxidation rates for at least seven concentrations of substrate were measured at 37C
and pH 7 and kinetic constants (K„, K, and V, values) were calculated as previously described …

The concept of co-production – also called co-creation – is gaining widespread attention as
a way to increase user involvement in service provision in the UK. It is usually taken as self-…

… The prior is B(7,3), indicating prior knowledge that high conservation is found in interaction
sites; it corresponds to adding seven pseudocounts to the C = high category, and three to C = …