This paper reports the cardiovascular effects of intentionally toxic intravenous doses of
lidocaine, bupivacaine, and ropivacaine and the mechanisms of death. Fatal doses of lidocaine, …

All currently available aminoacylaniline local anaesthetics, except lignocaine, contain a chiral
centre but are used as racemates, a fact usually ignored in pharmacokinetic studies. This …

1. Pharmacokinetic data for propofol, a new intravenous anaesthetic agent, indicate that
there may be extensive extrahepatic clearance. This was investigated during intravenous …

rac‐Bupivacaine HCl was infused intravenously to constant arterial blood drug concentrations
in sheep using a regimen of 4 mg/min for 15 min followed by 1 mg/min to 24 h. At 24 h, …

The influence of experimentally induced renal failure on the disposition of morphine,
morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) was examined in seven sheep …

In a crossover design study we have measured the total body and regional clearances of
morphine. Thirteen experiments were performed in four conscious sheep that had been …

The effects of gender and oral contraceptive steroids on the pharmacokinetics of (R)‐ibuprofen
were studied in groups of healthy adult males, females and oral contraceptive steroid (…

A method for the determination of fentanyl blood concentrations using gas liquid chromatography
coupled to a nitrogen phosphorus detector (NPD) is presented. A highly inert fused-…

The purpose of this study was to determine the cardiovascular effects and the total body and
regional clearances of ropivacaine during its continuous intravenous infusion to subtoxic …

A sheep preparation has been developed which allows systematic direct studies into the
sites and rates of distribution, formation and elimination of both endogenous and exogenous …