Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin

…, CJ Bacchi, DL Kramer, CW Porter - Biochemical …, 2002 - portlandpress.com
During polyamine catabolism, spermine and spermidine are first acetylated by spermidine/spermine
N 1 -acetyltransferase (SSAT) and subsequently oxidized by polyamine oxidase (…

[PDF][PDF] Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

…, JA Old, LM Nilsson, G Neale, DL Kramer, CW Porter… - Cancer cell, 2005 - cell.com
Checkpoints that control Myc-mediated proliferation and apoptosis are bypassed during
tumorigenesis. Genes encoding polyamine biosynthetic enzymes are overexpressed in B cells …

Autoradiographic distribution of hematoporphyrin derivative in normal and tumor tissue of the mouse

PJ Bugelski, CW Porter, TJ Dougherty - Cancer Research, 1981 - AACR
The distribution of isotopically labeled hematoporphyrin derivative (HPD) has been studied
in mice bearing the spontaneous mammary tumor (fast growing). In stomach, liver, spleen, …

Methylthioadenosine Phosphorylase, a Gene Frequently Codeleted with p16cdkN2a/ARF, Acts as a Tumor Suppressor in a Breast Cancer Cell Line

SA Christopher, P Diegelman, CW Porter, WD Kruger - Cancer research, 2002 - AACR
The human methylthioadenosine phosphorylase (MTAP) gene is located on 9p21 and is
frequently homozygously deleted, along with p16 cdkN2a/ARF , in a wide variety of human …

Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene

O Shi, SM Morris Jr, H Zoghbi, CW Porter… - … and cellular biology, 2001 - Taylor & Francis
Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component
of the urea cycle, and inherited defects in arginase I have deleterious consequences in …

[HTML][HTML] Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA

…, KK Deeb, L Alhonen, MS Patel, CW Porter - Journal of Biological …, 2007 - ASBMB
The acetylating enzyme, spermidine/spermine N 1 -acetyltransferase, participates in polyamine
homeostasis by regulating polyamine export and catabolism. Previously, we reported …

Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion

…, P Diegelman, DL Kramer, CW Porter - Biochemical …, 2003 - portlandpress.com
In the polyamine back-conversion pathway, spermine and spermidine are first acetylated by
spermidine/spermine N 1 -acetyltransferase (SSAT) and then oxidized by polyamine …

Differential Induction of Spermidine/Spermine N1-Acetyltransferase in Human Lung Cancer Cells by the Bis(ethyl)polyamine Analogues

RA Casero Jr, P Celano, SJ Ervin, CW Porter… - Cancer Research, 1989 - AACR
We have investigated the induction of an important polyamine metabolic enzyme,
spermidine/spermine N 1 -acetyltransferase, in two human lung cancer cell lines which respond …

CGP 48664, a New S-Adenosylmethionine Decarboxylase Inhibitor with Broad Spectrum Antiproliferative and Antitumor Activity

…, H Mett, J Stanek, M Mueller, D Kramer, CW Porter - Cancer research, 1994 - AACR
Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC),
derived from methylglyoxal-bis(guanylhydrazone) (MGBG), have been shown to have …

Correlations between Polyamine Analogue-induced Increases in Spermidine/Spermine N1-Acetyltransferase Activity, Polyamine Pool Depletion, and Growth …

CW Porter, B Ganis, PR Libby, RJ Bergeron - Cancer research, 1991 - AACR
The polyamine analogue, N 1 ,N 12 -bis(ethyl)spermine (BESPM), is known to suppress
ornithine and S-adenosylmethionine decarboxylase levels, deplete intracellular polyamine pools…