Purpose: To characterize the population pharmacokinetics of trastuzumab in patients with
metastatic breast cancer. Methods: A nonlinear mixed effect model was based on …

Many purine nucleosides and their analogs are actively transported in the kidney. Using
homology cloning strategies and reverse transcriptase-polymerase chain reactions, we isolated …

The anti-HIV protease inhibitors represent a new class of agents for treatment of HIV infection.
Saquinavir, ritonavir, indinavir, and nelfinavir are the first drugs approved in this class and …

Recently, we cloned a human organic cation transporter, hOCT1, which is expressed
primarily in the liver. hOCT1 plays an important role in the cellular uptake and elimination of …

Protease inhibitors are very effective in treating patients infected with HIV. However, many
drugs in this class penetrate poorly into the central nervous system (CNS) and may permit this …

The S-oxygenation of cimetidine was investigated using achiral chemical and chiral chemical
and enzymatic S-oxygenation procedures. The products of the reactions were thoroughly …

The therapeutic efficacy of nucleosides and nucleoside analogues as antitumor, antiviral,
antiparasitic, and antiarrhythmic agents has been well documented. Pharmacokinetic studies …

Background: Sickle cell disease (SCD) is a genetic disorder in which deoxygenation produces
polymerization of mutated hemoglobin S (HbS) and triggers the downstream effects of red …

The overall goal of this study was to determine the mechanisms by which nucleobases are
transported in the choroid plexus. Choroid plexus tissue slices were obtained from the lateral …

Sickle cell disease (SCD) is characterized by the production of sickle hemoglobin (HbS),
which when deoxygenated, polymerizes leading to red blood cell damage and hemolytic …