SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
…, M Van Hoosear, Y Shin, DN Chin, CG Keller… - Nature chemical …, 2015 - nature.com
Spinal muscular atrophy (SMA), which results from the loss of expression of the survival of
motor neuron-1 (SMN1) gene, represents the most common genetic cause of pediatric …
motor neuron-1 (SMN1) gene, represents the most common genetic cause of pediatric …
Scalable chemical synthesis of doped silicon nanowires for energy applications
A versatile, low-cost and easily scalable synthesis method is presented for producing silicon
nanowires (SiNWs) as a pure powder. It applies air-stable diphenylsilane as a Si source …
nanowires (SiNWs) as a pure powder. It applies air-stable diphenylsilane as a Si source …
[HTML][HTML] An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion
CG Keller, Y Shin, AM Monteys, N Renaud… - Nature …, 2022 - nature.com
Huntington’s Disease (HD) is a progressive neurodegenerative disorder caused by CAG
trinucleotide repeat expansions in exon 1 of the huntingtin (HTT) gene. The mutant HTT (mHTT) …
trinucleotide repeat expansions in exon 1 of the huntingtin (HTT) gene. The mutant HTT (mHTT) …
[HTML][HTML] DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery
Here we report Digital RNA with pertUrbation of Genes (DRUG-seq), a high-throughput
platform for drug discovery. Pharmaceutical discovery relies on high-throughput screening, yet …
platform for drug discovery. Pharmaceutical discovery relies on high-throughput screening, yet …
[PDF][PDF] Transcriptome-wide changes in gene expression, splicing, and lncRNAs in response to a live attenuated dengue virus vaccine
…, HJ Dean, R Lorenzo-Redondo, M Stewart, CK Keller… - Cell reports, 2022 - cell.com
The tetravalent dengue vaccine candidate, TAK-003, induces a functional antibody response,
but the titers of antibodies against the four serotypes of the dengue virus (DENV) can vary. …
but the titers of antibodies against the four serotypes of the dengue virus (DENV) can vary. …
[PDF][PDF] YAP, but not RSPO-LGR4/5, signaling in biliary epithelial cells promotes a ductular reaction in response to liver injury
…, LM Terracciano, C Russ, JS Reece-Hoyes, CG Keller… - Cell stem cell, 2019 - cell.com
Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …
A scalable silicon nanowires-grown-on-graphite composite for high-energy lithium batteries
Silicon (Si) is the most promising anode candidate for the next generation of lithium-ion
batteries but difficult to cycle due to its poor electronic conductivity and large volume change …
batteries but difficult to cycle due to its poor electronic conductivity and large volume change …
[HTML][HTML] Effect of size and shape on electrochemical performance of nano-silicon-based lithium battery
C Keller, A Desrues, S Karuppiah, E Martin, JP Alper… - Nanomaterials, 2021 - mdpi.com
Silicon is a promising material for high-energy anode materials for the next generation of
lithium-ion batteries. The gain in specific capacity depends highly on the quality of the Si …
lithium-ion batteries. The gain in specific capacity depends highly on the quality of the Si …
[HTML][HTML] Recurrent miscarriages and the association with regulatory T cells; A systematic review
CC Keller, M Eikmans, MLP van der Hoorn… - Journal of reproductive …, 2020 - Elsevier
Regulatory T cells (Tregs) are essential in tolerizing the maternal immune system toward the
semi-allogeneic embryo. In this systematic review, we evaluated the association of levels …
semi-allogeneic embryo. In this systematic review, we evaluated the association of levels …
Genetic variation underlying differential ammonium and nitrate responses in Arabidopsis thaliana
Nitrogen is an essential element required for plant growth and productivity. Understanding
the mechanisms and natural genetic variation underlying nitrogen use in plants will facilitate …
the mechanisms and natural genetic variation underlying nitrogen use in plants will facilitate …