An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes

JH Ansede, WR Smith, CH Perry, RLS Claire… - Drug Metabolism and …, 2010 - ASPET
Drug-induced cholestasis can result from the inhibition of biliary efflux of bile acids in the
liver. Drugs may inhibit the hepatic uptake and/or the biliary efflux of bile acids resulting in an …

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

TL Marion, CH Perry, RLS Claire III… - Toxicology and applied …, 2012 - Elsevier
Sandwich-cultured hepatocytes (SCH) are used commonly to investigate hepatic transport
protein-mediated uptake and biliary excretion of substrates. However, little is known about the …

Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes

TL Marion, CH Perry, RL St. Claire III… - Toxicological …, 2011 - academic.oup.com
Inhibition of bile acid (BA) transport may contribute to the hepatotoxicity of troglitazone (TRO),
a peroxisome proliferator–activated receptor gamma agonist. Typically, studies use …

Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes

LTM Griffin, PB Watkins, CH Perry, RLS Claire… - Drug Metabolism and …, 2013 - ASPET
Inhibition of the bile salt export pump (BSEP) can cause intracellular accumulation of bile
acids and is a risk factor for drug-induced liver injury in humans. Antiretroviral protease …

Automated applications of sandwich-cultured hepatocytes in the evaluation of hepatic drug transport

CH Perry, WR Smith, RL St. Claire III… - Journal of …, 2011 - journals.sagepub.com
Predictions of the absorption, distribution, metabolism, excretion, and toxicity of compounds
in pharmaceutical development are essential aspects of the drug discovery process. B-…

Opacity measurements: Extending the range and filling in the gaps

CA Back, TS Perry, DR Bach, BG Wilson… - Journal of Quantitative …, 1997 - Elsevier
CASSANDRA h is a second generation opacity code which uses the Dirac-Hartree-Slater
average atom models” with Gunnarsson-Lundqvist exchange ‘? to calculate a self-consistent …

Developing and evaluating rapid field methods to estimate peat carbon

RA Chimner, CA Ott, CH Perry, RK Kolka - Wetlands, 2014 - Springer
Many international protocols (eg, REDD+) are developing inventories of ecosystem carbon
stocks and fluxes at country and regional scales, which can include peatlands. As the only …

[PDF][PDF] Law & public policy

SG DOKUPIL, EB COLLINS, NJ MOSS… - Harvard-Jlpp …, 1993 - journals.law.harvard.edu
CASSANDRA H. WELCH … SCOTT H. LINTON … PERRY JOHN PLAYFORTH PAUL
RIETEMA ALLISON RONE STEWART SALWIN BEN SWEET MEIKA VOGEL …

[CITATION][C] St Claire, and Kenneth R. Brouwer. 2010. An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat …

JH Ansede, WR Smith, CH Perry, L Robert - Drug Metabolism and Disposition

[CITATION][C] Predicting Transporter-Mediated Drug-Drug Interactions Based on the B-CLEAR (R)-Rapid Transport Screen in Sandwich-Cultured Hepatocytes

JK Lee, CH Perry, C Parsons… - DRUG …, 2010 - … & FRANCIS INC 325 CHESTNUT ST …