The prevalence of obesity in adults and children is rapidly increasing across the world.
Several general (patho)physiological alterations associated with obesity have been described, …

Children differ from adults in their response to drugs. While this may be the result of changes
in dose exposure (pharmacokinetics [PK]) and/or exposure response (pharmacodynamics […

Patient groups prone to polypharmacy and special subpopulations are susceptible to
suboptimal treatment. Refined dosing in special populations is imperative to improve therapeutic …

Background Pain in critically ill patients in the intensive care unit (ICU) is common. However,
pain assessment in critically ill patients often is complicated because these patients are …

Importance Continuous morphine infusion as standard postoperative analgesic therapy in
young infants is associated with unwanted adverse effects such as respiratory depression. …

Background Anti-thymocyte globulin (ATG) was introduced into the conditioning regimen in
haemopoietic cell transplantation (HCT) to prevent graft-versus-host-disease (GvHD) and …

BACKGROUND: Assessing pain in mechanically ventilated critically ill patients is a great
challenge. There is a need for an adequate pain measurement tool for use in conscious …

Background Anti-thymocyte globulin (ATG) is used to prevent graft-versus-host disease (GvHD)
after allogeneic haemopoietic cell transplantation (HCT). However, ATG can also cause …

Introduction: The rising prevalence of obesity confronts clinicians with dosing problems in the
(extreme) overweight population. Obesity has a great impact on key organs that play a role …

Objective: This study examines the influence of patient demographics and peri- and postoperative
(≪7 days) characteristics on the incidence of chronic thoracic pain 1 year after cardiac …