Méthodes: Nous avons conduit une étude prospective, descriptive chez 1047 enfants
consécutivement admis sur une période d'un an dans une USI pédiatrique. L'IRA était définie …

Rationale: Vasopressin has been proposed as a potent vasoactive agent in the treatment of
vasodilatory shock in adults and children. The objective of this trial was to evaluate the …

Nonsteroidal anti-inflammatory drugs (NSAIDs) possess antipyretic, analgesic and anti-inflammatory
effects. They are frequently used in children and have numerous therapeutic …

Cytochromes P450 3A (CYP3A) and P-glycoprotein (P-gp) are mainly located in enterocytes
and hepatocytes. The CYP3A/P-gp system contributes to the first-pass metabolism of many …

The use of proton pump inhibitors (PPIs) has become widespread in children and infants for
the management of paediatric acid-related disease. Pharmacokinetic profiles of only …

Background Propofol is commonly used to anesthetize children undergoing
esophagogastroduodenoscopy. Opioids are often used in combination with propofol to provide total …

Developing suitable paediatric formulations and ensuring access to them by the greatest
number of the 2.2 billion children worldwide are equally important to provide optimal …

Experimental data suggest that the host’s inflammatory response is involved in the
pathophysiology of verotoxin-producing Escherichia coli (VTEC)-associated hemolytic uremic …

Objective: We conducted a meta-analysis by using summary receiver operating characteristic
curves to compare the diagnostic value for bacterial nosocomial pneumonia of the …

Aims The aim of this study is to develop a population pharmacokinetic (PopPK) model for
intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the main …