User profiles for Charles Steenbergen

Charles Steenbergen

Division of Cardiovascular Pathology, Johns Hopkins
Verified email at jhmi.edu
Cited by 25693

Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury

E Murphy, C Steenbergen - Physiological reviews, 2008 - journals.physiology.org
Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium (…

2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology

…, JE Saffitz, MN Sheppard, C Steenbergen… - Cardiovascular …, 2012 - Elsevier
The Association for European Cardiovascular Pathology and the Society for Cardiovascular
Pathology have produced this position paper concerning the current role of endomyocardial …

Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing

…, M Reinblatt, C Steenbergen… - Proceedings of the …, 2011 - National Acad Sciences
Neovascularization is a critical determinant of wound-healing outcomes for deep burn
injuries. We hypothesize that dextran-based hydrogels can serve as instructive scaffolds to …

Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy

…, ST Lee, RR Smith, AC Lardo, S Lai, C Steenbergen… - Circulation, 2009 - Am Heart Assoc
Background— Cardiosphere-derived cells (CDCs) isolated from human endomyocardial
biopsies reduce infarct size and improve cardiac function in mice. Safety and efficacy testing in …

Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart.

C Steenbergen, E Murphy, L Levy… - Circulation research, 1987 - Am Heart Assoc
Changes in cytosolic free calcium concentration during myocardial ischemia were measured
by 19F NMR in 5FBAPTA-loaded perfused rat hearts. The hearts were perfused with Krebs-…

Phosphorylation of glycogen synthase kinase-3β during preconditioning through a phosphatidylinositol-3-kinase–dependent pathway is cardioprotective

H Tong, K Imahashi, C Steenbergen… - Circulation research, 2002 - Am Heart Assoc
We previously reported that activation of phosphatidylinositol-3-kinase (PI3-kinase) is involved
in ischemic preconditioning (PC). Our goal was to determine downstream targets of PI3-…

Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure.

…, J Schaper, ML Hill, C Steenbergen Jr… - Circulation …, 1985 - Am Heart Assoc
The acute effects of reperfusion on myocardium reversibly damaged by 15 minutes of
severe ischemia in vivo, were studied. Changes in the adenine nucleotide pool, cell volume …

Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism

RA Forbes, C Steenbergen, E Murphy - Circulation research, 2001 - Am Heart Assoc
Diazoxide, a selective opener of the mitochondrial ATP-sensitive potassium channel, has
been shown to elicit tolerance to ischemia in cardiac myocytes and in perfused heart. However…

Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C

H Tong, W Chen, C Steenbergen, E Murphy - Circulation research, 2000 - Am Heart Assoc
The present study is designed to test whether phosphatidylinositol 3-kinase (PI3-kinase) has
a role in the signaling pathway in ischemic preconditioning (PC) and whether it is proximal …

Preconditioning Results in S-Nitrosylation of Proteins Involved in Regulation of Mitochondrial Energetics and Calcium Transport

J Sun, M Morgan, RF Shen, C Steenbergen… - Circulation …, 2007 - Am Heart Assoc
Nitric oxide has been shown to be an important signaling messenger in ischemic preconditioning
(IPC). Accordingly, we investigated whether protein S-nitrosylation occurs in IPC hearts …