User profiles for Charles Steenbergen
Charles SteenbergenDivision of Cardiovascular Pathology, Johns Hopkins Verified email at jhmi.edu Cited by 25693 |
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury
E Murphy, C Steenbergen - Physiological reviews, 2008 - journals.physiology.org
Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium (…
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium (…
2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology
…, JE Saffitz, MN Sheppard, C Steenbergen… - Cardiovascular …, 2012 - Elsevier
The Association for European Cardiovascular Pathology and the Society for Cardiovascular
Pathology have produced this position paper concerning the current role of endomyocardial …
Pathology have produced this position paper concerning the current role of endomyocardial …
Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing
…, M Reinblatt, C Steenbergen… - Proceedings of the …, 2011 - National Acad Sciences
Neovascularization is a critical determinant of wound-healing outcomes for deep burn
injuries. We hypothesize that dextran-based hydrogels can serve as instructive scaffolds to …
injuries. We hypothesize that dextran-based hydrogels can serve as instructive scaffolds to …
Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy
Background— Cardiosphere-derived cells (CDCs) isolated from human endomyocardial
biopsies reduce infarct size and improve cardiac function in mice. Safety and efficacy testing in …
biopsies reduce infarct size and improve cardiac function in mice. Safety and efficacy testing in …
Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart.
C Steenbergen, E Murphy, L Levy… - Circulation research, 1987 - Am Heart Assoc
Changes in cytosolic free calcium concentration during myocardial ischemia were measured
by 19F NMR in 5FBAPTA-loaded perfused rat hearts. The hearts were perfused with Krebs-…
by 19F NMR in 5FBAPTA-loaded perfused rat hearts. The hearts were perfused with Krebs-…
Phosphorylation of glycogen synthase kinase-3β during preconditioning through a phosphatidylinositol-3-kinase–dependent pathway is cardioprotective
H Tong, K Imahashi, C Steenbergen… - Circulation research, 2002 - Am Heart Assoc
We previously reported that activation of phosphatidylinositol-3-kinase (PI3-kinase) is involved
in ischemic preconditioning (PC). Our goal was to determine downstream targets of PI3-…
in ischemic preconditioning (PC). Our goal was to determine downstream targets of PI3-…
Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure.
…, J Schaper, ML Hill, C Steenbergen Jr… - Circulation …, 1985 - Am Heart Assoc
The acute effects of reperfusion on myocardium reversibly damaged by 15 minutes of
severe ischemia in vivo, were studied. Changes in the adenine nucleotide pool, cell volume …
severe ischemia in vivo, were studied. Changes in the adenine nucleotide pool, cell volume …
Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism
RA Forbes, C Steenbergen, E Murphy - Circulation research, 2001 - Am Heart Assoc
Diazoxide, a selective opener of the mitochondrial ATP-sensitive potassium channel, has
been shown to elicit tolerance to ischemia in cardiac myocytes and in perfused heart. However…
been shown to elicit tolerance to ischemia in cardiac myocytes and in perfused heart. However…
Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C
H Tong, W Chen, C Steenbergen, E Murphy - Circulation research, 2000 - Am Heart Assoc
The present study is designed to test whether phosphatidylinositol 3-kinase (PI3-kinase) has
a role in the signaling pathway in ischemic preconditioning (PC) and whether it is proximal …
a role in the signaling pathway in ischemic preconditioning (PC) and whether it is proximal …
Preconditioning Results in S-Nitrosylation of Proteins Involved in Regulation of Mitochondrial Energetics and Calcium Transport
J Sun, M Morgan, RF Shen, C Steenbergen… - Circulation …, 2007 - Am Heart Assoc
Nitric oxide has been shown to be an important signaling messenger in ischemic preconditioning
(IPC). Accordingly, we investigated whether protein S-nitrosylation occurs in IPC hearts …
(IPC). Accordingly, we investigated whether protein S-nitrosylation occurs in IPC hearts …