For an electron microscopic study of the liver, expertise and complicated, time-consuming
processing of hepatic tissues and cells is needed. The interpretation of electron microscopy (…

Human hepatocytes were transplanted into urokinase-type plasminogen activator-transgenic
SCID mice (uPA/SCID mice), which are immunodeficient and undergo liver failure. The …

Proteome analysis was performed on cellular and secreted proteins of normal (quiescent)
and activated rat hepatic stellate cells. The stellate cells were activated either in vitro by …

Recently, chimeric mice with humanized liver were established by transplanting human
hepatocytes into an urokinase-type plasminogen activator +/+ /severe combined …

Studies of hepatitis B virus (HBV) mutants have been hampered by the lack of a small animal
model with long‐term infection of cloned HBV. Using a mouse model in which liver cells …

We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen
activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice …

The molecular mechanisms underlying the hepatitis B virus (HBV) life cycle are poorly
understood because of the lack of appropriate in vitro infection models. Herein, we report a highly …

While the 2002–2003 outbreak of severe acute respiratory syndrome (SARS) resulted in 774
deaths, patients who were affected with mild pulmonary symptoms successfully recovered. …

Following genomics and proteomics, cytomics, a novel method of looking at life, has emerged
for analyzing large populations of cells on a single‐cell basis with multiple parameters in a …

Advancement in both bioengineering and cell biology of the liver led to the establishment of
the first-generation humanized liver chimeric mouse (HLCM) model in 2001. The HLCM …