Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important
paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have …

The efficacy, safety, and tolerability of drugs are dependent on numerous factors that influence
their disposition. A dose that is efficacious and safe for one individual may result in sub-…

Epilepsy is a heterogenous neurological disorder characterized by recurrent unprovoked
seizures, mitochondrial stress, and neurodegeneration. Hydrogen sulfide (H 2 S) is a …

Metabolic phenotype can be affected by multiple factors, including allelic variation and
interactions with inhibitors. Human CYP2D6 is responsible for approximately 20% of cytochrome …

The seminal discovery that cytochrome P450 enzymes (CYPs) can oxidize polyunsaturated
fatty acids (PUFAs) sparked a new area of research aimed at discovering the role of these …

Epilepsy is a heterogenous neurological disorder characterized by recurrent unprovoked
seizures, mitochondrial stress, and neurodegeneration. Hydrogen sulfide (H2S), a …

CYP2J2 is the only member of the human CYP2J family, and its expression is largely
extrahepatic. The highest expression of human CYP2J2 is in the heart, where its major …

Cytochrome P450s (CYPs) are a superfamily of heme‐containing enzymes that are
responsible for the metabolism of many xenobiotics and other small endogenous substrates. …

To assess DNA repair activity relative to age, in vitro base excision repair assays were
performed using brain and liver nuclear extracts prepared from mice of various ages. An 85% …

This dissertation presents the Eucharist as both liturgical and discursive space, and the act of
writing as an aid to sacramental practice. I first focus my attention on the uneasy paradox of …