Mercapturic acid urinary metabolites of 3-butene-1, 2-diol as in vivo evidence for the formation of hydroxymethylvinyl ketone in mice and rats
CL Sprague, AA Elfarra - Chemical research in toxicology, 2004 - ACS Publications
3-Butene-1,2-diol (BDD), a major metabolite of 1,3-butadiene (BD), can readily be oxidized
to hydroxymethylvinyl ketone (HMVK), a Michael acceptor. In previous studies, 4-(N-acetyl-l-…
to hydroxymethylvinyl ketone (HMVK), a Michael acceptor. In previous studies, 4-(N-acetyl-l-…
Species and tissue differences in the toxicity of 3-butene-1, 2-diol in male Sprague-Dawley rats and B6C3F1 mice
CL Sprague, LA Phillips, KM Young… - Toxicological …, 2004 - academic.oup.com
3-Butene-1,2-diol (BDD) is a major metabolite of 1,3-butadiene (BD), but the role of BDD in
BD toxicity and carcinogenicity remains unclear. In this study, the acute toxicity of BDD was …
BD toxicity and carcinogenicity remains unclear. In this study, the acute toxicity of BDD was …
Protection of rats against 3-butene-1, 2-diol-induced hepatotoxicity and hypoglycemia by N-acetyl-l-cysteine
CL Sprague, AA Elfarra - Toxicology and applied pharmacology, 2005 - Elsevier
3-Butene-1,2-diol (BDD), an allylic alcohol and major metabolite of 1,3-butadiene, has
previously been shown to cause hepatotoxicity and hypoglycemia in male Sprague–Dawley rats, …
previously been shown to cause hepatotoxicity and hypoglycemia in male Sprague–Dawley rats, …
Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1, 2-diol, a major metabolite of 1, 3-butadiene
CL Sprague, AA Elfarra - Drug metabolism and disposition, 2003 - ASPET
Epidemiological studies have indicated that 1,3-butadiene exposure is associated with an
increased risk of leukemia. In human liver microsomes, 1,3-butadiene is rapidly oxidized to …
increased risk of leukemia. In human liver microsomes, 1,3-butadiene is rapidly oxidized to …
Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections
…, C Caporuscio, DW Boulton, LJ Christopher… - Drug metabolism and …, 2009 - ASPET
… (1.3–5.2 l/kg) and predicted for humans (2.7 l/kg) were greater … After intra-arterial administration
of saxagliptin to Sprague-… of 1.3 to 5.2 l/kg, higher than those for total body water (0.7 l/kg)…
of saxagliptin to Sprague-… of 1.3 to 5.2 l/kg, higher than those for total body water (0.7 l/kg)…
Lacteal secretion, fetal and maternal tissue distribution of dasatinib in rats
…, WC Shyu, WG Humphreys, LJ Christopher - Drug Metabolism and …, 2008 - ASPET
… Dasatinib exhibited extensive lacteal secretion in Sprague-Dawley rats following a single …
After a single dose of [ 14 C]dasatinib to pregnant Sprague-Dawley rats at gestation day 18, …
After a single dose of [ 14 C]dasatinib to pregnant Sprague-Dawley rats at gestation day 18, …
Variation in mammographic breast density assessments among radiologists in clinical practice: a multicenter observational study
BL Sprague, EF Conant, T Onega… - Annals of internal …, 2016 - acpjournals.org
Background: About half of the United States has legislation requiring radiology facilities to
disclose mammographic breast density information to women, often with language …
disclose mammographic breast density information to women, often with language …
Characterization of organic anion transporter 2 (SLC22A7): a highly efficient transporter for creatinine and species-dependent renal tubular expression
…, AC Lewin, XT Wang, G Liu, LJ Christopher… - Drug Metabolism and …, 2015 - ASPET
The contribution of organic anion transporter OAT2 (SLC22A7) to the renal tubular secretion
of creatinine and its exact localization in the kidney are reportedly controversial. In the …
of creatinine and its exact localization in the kidney are reportedly controversial. In the …
Biotransformation of [14C] dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys
LJ Christopher, D Cui, W Li, A Barros, VK Arora… - Drug Metabolism and …, 2008 - ASPET
This study describes the in vitro metabolism of [ 14 C]dasatinib in liver tissue incubations
from rat, monkey, and human and the in vivo metabolism in rat and monkey. Across species, …
from rat, monkey, and human and the in vivo metabolism in rat and monkey. Across species, …
National performance benchmarks for modern screening digital mammography: update from the Breast Cancer Surveillance Consortium
Purpose To establish performance benchmarks for modern screening digital mammography
and assess performance trends over time in US community practice. Materials and Methods …
and assess performance trends over time in US community practice. Materials and Methods …