Past publications have highlighted the influence of postdialysis plasma pH on the measured
fraction unbound in plasma (fup). There is disparity in the industry as to which of two main …

The purpose of the study was to examine the potential of inhibition of cathepsin S as a treatment
for autoimmune diseases. A highly selective cathepsin S inhibitor, CSI-75, was shown to …

Endothelin receptors bind peptides of the endothelin family, the most potent vasoconstrictors
known, and have been implicated in hypertension. To begin to define DNA sequences …

Background Vitamin D was used to treat tuberculosis in the pre-antibiotic era, and its
metabolites induce antimycobacterial immunity in vitro. Clinical trials investigating the effect of …

These findings reveal that a high frequency of Eomes + T-bet low CD8 + T cells predicts
poor clinical outcome in AML and that targeting Eomes may provide a therapeutic benefit …

ABSTRACT Treatment of acute myeloid leukemia (AML) remains challenging. Enhancement
of anti-tumor responses by blocking negative immune regulators is a promising strategy for …

Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in
patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine …

Acute myeloid leukemia (AML) is a devastating blood cancer with 5-year survival of only 25%.
Novel effective leukemia therapy is an urgent unmet need. Immunotherapy is a promising …

… Claxton et al. 340 … Claxton et al. 342 … Claxton K, Posnett J. An economic approach to
clinical trial design and research priority-setting. Health Econ 1996; 5: 513–524. …

Objective: To evaluate the cost effectiveness of four disease modifying treatments (interferon
betas and glatiramer acetate) for relapsing remitting and secondary progressive multiple …