User profiles for Chul-Ho Yun
Chul-Ho YunChonnam National University Verified email at jnu.ac.kr Cited by 7812 |
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat.
M Sattler, FP Guengerich, CH Yun, U Christians… - Drug metabolism and …, 1992 - ASPET
The hepatic cytochrome P-450 responsible for metabolism of the structurally related
macrolides FK506 and rapamycin in humans was identified using in vitro studies. FK506 and …
macrolides FK506 and rapamycin in humans was identified using in vitro studies. FK506 and …
The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities
The use of cytochrome P450 (P450 or CYP) enzymes as biocatalysts for the production of
fine chemicals, including pharmaceuticals, has been of increasing interest, primarily owing to …
fine chemicals, including pharmaceuticals, has been of increasing interest, primarily owing to …
[HTML][HTML] Light-driven biocatalytic oxidation
Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired
approaches for sustainable chemical synthesis. Oxidative enzymes (eg, monooxygenases, …
approaches for sustainable chemical synthesis. Oxidative enzymes (eg, monooxygenases, …
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver …
An acetyltransferase-overexpressing strain of Salmonella typhimurium (NM2009) has been
used to investigate roles of human liver microsomal cytochrome P450 (P450) enzymes in the …
used to investigate roles of human liver microsomal cytochrome P450 (P450) enzymes in the …
Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A (4) in N-dealkylation and C-hydroxylation.
CH Yun, RA Okerholm, FP Guengerich - Drug metabolism and Disposition, 1993 - ASPET
The antihistaminic drug terfenadine, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-
piperidinebutanol (Seldane), is of interest because of its lack of sedative …
piperidinebutanol (Seldane), is of interest because of its lack of sedative …
Biodegradation of polystyrene by bacteria from the soil in common environments
…, JH Jo, YB Kim, TK Le, CW Cho, CH Yun… - Journal of Hazardous …, 2021 - Elsevier
Polystyrene (PS), a major plastic waste, is difficult to biodegrade due to its unique chemical
structure that comprises phenyl moieties attached to long linear alkanes. In this study, we …
structure that comprises phenyl moieties attached to long linear alkanes. In this study, we …
[HTML][HTML] Evidence for a 1-electron oxidation mechanism in N-dealkylation of N, N-dialkylanilines by cytochrome P450 2B1: kinetic hydrogen isotope effects, linear free …
FP Guengerich, CH Yun, TL Macdonald - Journal of Biological Chemistry, 1996 - ASBMB
Many enzymes catalyze N-dealkylations of alkylamines, including cytochrome P450 (P450)
and peroxidase enzymes. Peroxidases, exemplified by horseradish peroxidase (HRP), are …
and peroxidase enzymes. Peroxidases, exemplified by horseradish peroxidase (HRP), are …
Cofactor‐free light‐driven whole‐cell cytochrome P450 catalysis
Cytochromes P450 can catalyze various regioselective and stereospecific oxidation reactions
of non‐functionalized hydrocarbons. Here, we have designed a novel light‐driven platform …
of non‐functionalized hydrocarbons. Here, we have designed a novel light‐driven platform …
P450-driven plastic-degrading synthetic bacteria
Plastic contamination currently threatens a wide variety of ecosystems and presents damaging
repercussions and negative consequences for many wildlife species. Sustainable plastic …
repercussions and negative consequences for many wildlife species. Sustainable plastic …
Generation of the human metabolite piceatannol from the anticancer-preventive agent resveratrol by bacterial cytochrome P450 BM3
In recent studies, the wild-type and mutant forms of cytochrome P450 (P450) BM3 (CYP102A1)
from Bacillus megaterium were found to metabolize various drugs through reactions …
from Bacillus megaterium were found to metabolize various drugs through reactions …