User profiles for Chul-Ho Yun

Chul-Ho Yun

Chonnam National University
Verified email at jnu.ac.kr
Cited by 7812

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat.

M Sattler, FP Guengerich, CH Yun, U Christians… - Drug metabolism and …, 1992 - ASPET
The hepatic cytochrome P-450 responsible for metabolism of the structurally related
macrolides FK506 and rapamycin in humans was identified using in vitro studies. FK506 and …

The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities

CH Yun, KH Kim, DH Kim, HC Jung, JG Pan - Trends in biotechnology, 2007 - cell.com
The use of cytochrome P450 (P450 or CYP) enzymes as biocatalysts for the production of
fine chemicals, including pharmaceuticals, has been of increasing interest, primarily owing to …

[HTML][HTML] Light-driven biocatalytic oxidation

CH Yun, J Kim, F Hollmann, CB Park - Chemical Science, 2022 - pubs.rsc.org
Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired
approaches for sustainable chemical synthesis. Oxidative enzymes (eg, monooxygenases, …

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver …

H Yamazaki, Y Inui, CH Yun, FP Guengerich… - …, 1992 - academic.oup.com
An acetyltransferase-overexpressing strain of Salmonella typhimurium (NM2009) has been
used to investigate roles of human liver microsomal cytochrome P450 (P450) enzymes in the …

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A (4) in N-dealkylation and C-hydroxylation.

CH Yun, RA Okerholm, FP Guengerich - Drug metabolism and Disposition, 1993 - ASPET
The antihistaminic drug terfenadine, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-
piperidinebutanol (Seldane), is of interest because of its lack of sedative …

Biodegradation of polystyrene by bacteria from the soil in common environments

…, JH Jo, YB Kim, TK Le, CW Cho, CH Yun… - Journal of Hazardous …, 2021 - Elsevier
Polystyrene (PS), a major plastic waste, is difficult to biodegrade due to its unique chemical
structure that comprises phenyl moieties attached to long linear alkanes. In this study, we …

[HTML][HTML] Evidence for a 1-electron oxidation mechanism in N-dealkylation of N, N-dialkylanilines by cytochrome P450 2B1: kinetic hydrogen isotope effects, linear free …

FP Guengerich, CH Yun, TL Macdonald - Journal of Biological Chemistry, 1996 - ASBMB
Many enzymes catalyze N-dealkylations of alkylamines, including cytochrome P450 (P450)
and peroxidase enzymes. Peroxidases, exemplified by horseradish peroxidase (HRP), are …

Cofactor‐free light‐driven whole‐cell cytochrome P450 catalysis

…, DH Nam, JH Lee, JK Lee, CH Yun… - Angewandte …, 2015 - Wiley Online Library
Cytochromes P450 can catalyze various regioselective and stereospecific oxidation reactions
of non‐functionalized hydrocarbons. Here, we have designed a novel light‐driven platform …

P450-driven plastic-degrading synthetic bacteria

SJ Yeom, TK Le, CH Yun - Trends in Biotechnology, 2022 - cell.com
Plastic contamination currently threatens a wide variety of ecosystems and presents damaging
repercussions and negative consequences for many wildlife species. Sustainable plastic …

Generation of the human metabolite piceatannol from the anticancer-preventive agent resveratrol by bacterial cytochrome P450 BM3

DH Kim, T Ahn, HC Jung, JG Pan, CH Yun - Drug metabolism and …, 2009 - ASPET
In recent studies, the wild-type and mutant forms of cytochrome P450 (P450) BM3 (CYP102A1)
from Bacillus megaterium were found to metabolize various drugs through reactions …