Structure and stereochemistry of the active metabolite of clopidogrel
…, M Pascal, JM Herbert, JP Maffrand, C Picard - Drug metabolism and …, 2002 - ASPET
Clopidogrel (SR25990C, PLAVIX) is a potent antiplatelet drug, which has been recently
launched and is indicated for the prevention of vascular thrombotic events in patients at risk. …
launched and is indicated for the prevention of vascular thrombotic events in patients at risk. …
Screening approach for chiral separation of pharmaceuticals: Part III. Supercritical fluid chromatography for analysis and purification in drug discovery
…, A Pradines, Y Vander Heyden, C Picard - … of Chromatography A, 2005 - Elsevier
High-throughput and performance analysis and purification of enantiomers are important
parts of drug discovery and provide high-quality compounds for pharmacological testing. We …
parts of drug discovery and provide high-quality compounds for pharmacological testing. We …
CB1 receptor‐mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus
…, P Ludwiczak, M Maftouh, C Picard… - European Journal of …, 2007 - Wiley Online Library
In the present study, we examined the occurrence and potential regulation of endocannabinoid
release by cannabinoid CB1 receptors in the rat brain. To this end, we developed a …
release by cannabinoid CB1 receptors in the rat brain. To this end, we developed a …
The Immunosuppressant SR 31747 Blocks Cell Proliferation by Inhibiting a Steroid Isomerase in Saccharomyces cerevisiae
…, C Lanau, M Kaghad, C Dhers, C Picard… - … and Cellular Biology, 1996 - Taylor & Francis
SR 31747 is a novel immunosuppressant agent that arrests cell proliferation in the yeast
Saccharomyces cerevisiae. SR 31747-treated cells accumulate the same aberrant sterols as …
Saccharomyces cerevisiae. SR 31747-treated cells accumulate the same aberrant sterols as …
Antiproliferative effects of SR31747A in animal cell lines are mediated by inhibition of cholesterol biosynthesis at the sterol isomerase step
…, S Silve, C Lanau, C Dhers, C Picard… - European journal of …, 1998 - Wiley Online Library
SR31747A is a new sigma ligand exhibiting immunosuppressive properties and antiproliferative
activity on lymphocyte cells. Only two subtypes of sigma receptor, namely the sigma 1 …
activity on lymphocyte cells. Only two subtypes of sigma receptor, namely the sigma 1 …
Structural Elucidation of Novel Methylglucose‐Containing Polysaccharides from Mycobacterium xenopi
G Tuffal, C Ponthus, C Picard… - European journal of …, 1995 - Wiley Online Library
The structures of methylglucose‐containing polysaccharides (MeGlc PS) from Mycobacterium
xenopi were investigated using high‐pH anion‐exchange chromatography and liquid …
xenopi were investigated using high‐pH anion‐exchange chromatography and liquid …
Characterization of the deamidated forms of recombinant hirudin
…, C Ponthus, O Whitechurch, C Roitsch, C Picard - Biochemistry, 1992 - ACS Publications
Revised Manuscript Received May 13, 1992 abstract: Recombinant hirudin variant rHV2-Lys
47 (MW= 6906.5) was intentionally deamidated by incubation in pH 9 phosphate buffer at …
47 (MW= 6906.5) was intentionally deamidated by incubation in pH 9 phosphate buffer at …
Direct Evidence of Methylglucose Lipopolysaccharides/Palmitoyl-CoA Noncovalent Complexes by Capillary Zone Electrophoresis− Electrospray/Mass Spectrometry
…, C Dhers, F Uzabiaga, M Rivière, C Picard… - Analytical …, 1998 - ACS Publications
Mycobacterial methylglucose lipopolysaccharides (MGLPs) play an important regulatory role
in the biosynthesis of long-chain fatty acids by forming complexes with neosynthesized acyl-…
in the biosynthesis of long-chain fatty acids by forming complexes with neosynthesized acyl-…
Rat platelets contain glycosylated and non‐glycosylated forms of platelet factor 4: Identification and characterization by mass spectrometry
…, JC GUILLEMOT, F Uzabiaga, C Picard… - European journal of …, 1994 - Wiley Online Library
Platelet factor 4 is a heparin‐binding protein released from the α granules of activated platelets.
This study describes the purification and identification of two forms of rat platelet factor 4, …
This study describes the purification and identification of two forms of rat platelet factor 4, …
A DNA microarray-based approach to elucidate the effects of the immunosuppressant SR31747A on gene expression in Saccharomyces cerevisiae
…, S Silve, S Galiègue, C Dhers, C Picard… - … The Journal of Liver …, 2002 - ingentaconnect.com
SR31747A is an immunosuppressive agent that arrests cell proliferation in the yeast
Saccharomyces cerevisiae. In this microorganism, SR31747A was shown to inhibit the ERG2 gene …
Saccharomyces cerevisiae. In this microorganism, SR31747A was shown to inhibit the ERG2 gene …