1-Aminobenzotriazole (1-ABT) is generally considered to be a nonselective mechanism-based
inactivator of both human and non-human cytochrome P450 (P450) enzymes. Thus, 1-…

The metabolism of the 5-lipoxygenase inhibitor, 4-(3-(4-(2-methyl-1H-imidazol-1-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide
(CJ-13,610), was investigated in liver …

There is substantial interest in small molecules that can be used to detect or kill the hypoxic (low
oxygen) cells found in solid tumors. Nitroaryl moieties are useful components in the …

Suitably preserved specimens of animals and plants stored in museums and universities
constitute an invaluable, and for many species and many regions, irreplaceable resource that re…

Sandwich-cultured human hepatocytes (SCHH) have been widely used for in vitro assessments
of biliary clearance. However, the modulation of metabolism enzymes has not been fully …

Phragmites australis (Cav.) Trin. ex Steud. (common reed) is one of the most widespread
plant species in the world. The species has a high phenotypic variation in morphology and life-…

This report presents data collected as part of a reconnaissance study to evaluate the
occurrence of perchlorate in rivers and streams and in shallow aquifers in selected areas of the …

‘For sceptics and advocates of NLP, this book makes essential reading. The authors are an
international collaboration of researchers and writers lead by Lisa Wake, a leader in the NLP …

Populations of amphibians are in decline in certain locations around the world, and the
possible contribution of environmental contaminants, including estrogenic compounds, to these …

Joplin, Missouri, part of the Tri-State Mining District (TSMD), has a long history of mining that
resulted in mine waste piles proximal to the mines throughout the area. A local lead smelter …