Altered hepatic blood flow and drug disposition

AS Nies, DG Shand, GR Wilkinson - Clinical Pharmacokinetics, 1976 - Springer
… AS and Shand, DG: The disposition of propranolol VUl: General implications of the effects
of liver blood now on elimination from the perfused rat liver. Drug Metabolism and Disposition I…

A physiological approach to hepatic drug clearance

GR Wilkinson, DG Shand - Clinical Pharmacology & …, 1975 - Wiley Online Library
A physiological approach has been developed recognizing that hepatic blood flow, the activity
of the overall elimination process (intrinsic clearance), drug binding in the blood, and the …

Clinical pharmacokinetics of propranolol.

PA Routledge, DG Shand - Clinical pharmacokinetics, 1979 - europepmc.org
Propranolol is completely absorbed after oral administration and widely distributed throughout
tissues. Elimination occurs almost wholly by metabolic transformation in the liver and …

Clinical pharmacology of propranolol.

AS Nies, DG Shand - Circulation, 1975 - Am Heart Assoc
… CLEAVELAND CR, SHAND DG: Effect of route of administration on the relationship between
… CLEAVELAND CR, RANGNO RE, SHAND DG: A standardized isoproterenol sensitivity test. …

Effects of caffeine on plasma renin activity, catecholamines and blood pressure

…, JT Watson, JW Hollifield, DG Shand… - … England Journal of …, 1978 - Mass Medical Soc
Using a double-blind, randomized, crossover protocol, we studied the effect of a single dose
of oral caffeine on plasma renin activity, catecholamines and cardiovascular control in nine …

Reduced β‐adrenoceptor sensitivity in the elderly

RE Vestal, AJJ Wood, DG Shand - Clinical Pharmacology & …, 1979 - Wiley Online Library
… Wood AJJ, Carr K, Vestal RE, Belcher 0, Wilkinson GR, Shand DG: Direct measurement
of propranolol bioavailability during accumulation to steady state. Br J Clin Pharmacol 6:345-350…

Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.

…, GA Johnson, RM Robertson, AS Nies, DG Shand… - Circulation, 1979 - Am Heart Assoc
We assessed the release of neuronal and adrenomedullary catecholamines in response to
various stimuli of the sympathetic nervous system in normal subjects. Plasma …

Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance.

A Rane, GR Wilkinson, DG Shand - Journal of Pharmacology and …, 1977 - ASPET
Under first-order conditions the activity of the hepatic drug-metabolizing enzymes may be
closely approximated by the ratio of the in vitro kinetic constants Vmax and Km, which in turn is …

Plasma propranolol levels in adults with observations in four children

DG Shand, EM Nuckolls… - Clinical Pharmacology & …, 1970 - Wiley Online Library
Plasma levels of the f3‐adrenergic‐blocking drug, propranolol, have been measured
fluorometrically in man after oral and intravenous administration. Following oral administration, …

Pharmacokinetics and biodistribution of RGD-targeted doxorubicin-loaded nanoparticles in tumor-bearing mice

…, SG Kurz, KM Chytil, SE Barry, DG Shand… - International journal of …, 2005 - Elsevier
We report the biodistribution and pharmacokinetics (PK) of a cyclic RGD-doxorubicin-nanoparticle
(NP) formulation in tumor-bearing mice. The NP core was composed of inulin multi-…