Altered hepatic blood flow and drug disposition
AS Nies, DG Shand, GR Wilkinson - Clinical Pharmacokinetics, 1976 - Springer
… AS and Shand, DG: The disposition of propranolol VUl: General implications of the effects
of liver blood now on elimination from the perfused rat liver. Drug Metabolism and Disposition I…
of liver blood now on elimination from the perfused rat liver. Drug Metabolism and Disposition I…
A physiological approach to hepatic drug clearance
GR Wilkinson, DG Shand - Clinical Pharmacology & …, 1975 - Wiley Online Library
A physiological approach has been developed recognizing that hepatic blood flow, the activity
of the overall elimination process (intrinsic clearance), drug binding in the blood, and the …
of the overall elimination process (intrinsic clearance), drug binding in the blood, and the …
Clinical pharmacokinetics of propranolol.
PA Routledge, DG Shand - Clinical pharmacokinetics, 1979 - europepmc.org
Propranolol is completely absorbed after oral administration and widely distributed throughout
tissues. Elimination occurs almost wholly by metabolic transformation in the liver and …
tissues. Elimination occurs almost wholly by metabolic transformation in the liver and …
Clinical pharmacology of propranolol.
AS Nies, DG Shand - Circulation, 1975 - Am Heart Assoc
… CLEAVELAND CR, SHAND DG: Effect of route of administration on the relationship between
… CLEAVELAND CR, RANGNO RE, SHAND DG: A standardized isoproterenol sensitivity test. …
… CLEAVELAND CR, RANGNO RE, SHAND DG: A standardized isoproterenol sensitivity test. …
Effects of caffeine on plasma renin activity, catecholamines and blood pressure
…, JT Watson, JW Hollifield, DG Shand… - … England Journal of …, 1978 - Mass Medical Soc
Using a double-blind, randomized, crossover protocol, we studied the effect of a single dose
of oral caffeine on plasma renin activity, catecholamines and cardiovascular control in nine …
of oral caffeine on plasma renin activity, catecholamines and cardiovascular control in nine …
Reduced β‐adrenoceptor sensitivity in the elderly
RE Vestal, AJJ Wood, DG Shand - Clinical Pharmacology & …, 1979 - Wiley Online Library
… Wood AJJ, Carr K, Vestal RE, Belcher 0, Wilkinson GR, Shand DG: Direct measurement
of propranolol bioavailability during accumulation to steady state. Br J Clin Pharmacol 6:345-350…
of propranolol bioavailability during accumulation to steady state. Br J Clin Pharmacol 6:345-350…
Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.
…, GA Johnson, RM Robertson, AS Nies, DG Shand… - Circulation, 1979 - Am Heart Assoc
We assessed the release of neuronal and adrenomedullary catecholamines in response to
various stimuli of the sympathetic nervous system in normal subjects. Plasma …
various stimuli of the sympathetic nervous system in normal subjects. Plasma …
Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance.
A Rane, GR Wilkinson, DG Shand - Journal of Pharmacology and …, 1977 - ASPET
Under first-order conditions the activity of the hepatic drug-metabolizing enzymes may be
closely approximated by the ratio of the in vitro kinetic constants Vmax and Km, which in turn is …
closely approximated by the ratio of the in vitro kinetic constants Vmax and Km, which in turn is …
Plasma propranolol levels in adults with observations in four children
DG Shand, EM Nuckolls… - Clinical Pharmacology & …, 1970 - Wiley Online Library
Plasma levels of the f3‐adrenergic‐blocking drug, propranolol, have been measured
fluorometrically in man after oral and intravenous administration. Following oral administration, …
fluorometrically in man after oral and intravenous administration. Following oral administration, …
Pharmacokinetics and biodistribution of RGD-targeted doxorubicin-loaded nanoparticles in tumor-bearing mice
…, SG Kurz, KM Chytil, SE Barry, DG Shand… - International journal of …, 2005 - Elsevier
We report the biodistribution and pharmacokinetics (PK) of a cyclic RGD-doxorubicin-nanoparticle
(NP) formulation in tumor-bearing mice. The NP core was composed of inulin multi-…
(NP) formulation in tumor-bearing mice. The NP core was composed of inulin multi-…