Sol-gel/hydrothermal two-step synthesis strategy for promoting Ag species–modified TiO2-based composite activity toward H2 evolution under solar light

Q Zhu, N Liu, Q Ma, A Sharma, D Nagai, X Sun… - Materials Today …, 2021 - Elsevier
In this work, a facile one-pot sol-gel/hydrothermal two-step (SH II) process was developed to
synthesize the P/Ag/Ag 2 O/Ag 3 PO 4 /TiO 2 composite photocatalyst with superior H 2 …

Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl) phenyl] hydroxylamine, in human liver microsomes and urine of prostate cancer …

R Goda, D Nagai, Y Akiyama, K Nishikawa… - Drug metabolism and …, 2006 - ASPET
Flutamide (2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide), a nonsteroidal
antiandrogen, is used in the treatment of prostate cancer but is occasionally associated with …

Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity

M Ohbuchi, M Miyata, D Nagai, M Shimada… - Drug metabolism and …, 2009 - ASPET
Flutamide is used for prostate cancer therapy but occasionally induces severe liver injury.
Flutamide is hydrolyzed in the body into 5-amino-2-nitrobenzotrifluoride (FLU-1) and then …

Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice

Y Matsuzaki, D Nagai, E Ichimura, R Goda… - Journal of …, 2006 - Springer
Background Flutamide, a nonsteroidal antiandrogen used for treatment of prostate cancer,
causes a temporary increase in transaminase and in some cases severe liver dysfunction. It is …

Synthesis of 2‐Aminofurans by Sequential [2+ 2] Cycloaddition–Nucleophilic Addition of 2‐Propyn‐1‐ols with Tetracyanoethylene and Amine‐Induced Transformation …

T Shoji, D Nagai, M Tanaka, T Araki… - … A European Journal, 2017 - Wiley Online Library
Synthesis of 2‐aminofuran derivatives with an azulene or N,N‐dimethylanilino substituent was
established by the formal [2+2] cycloaddition–retroelectrocyclization of 3‐(1‐azulenyl or N,…

Synthesis and Properties of (3‐Phenyl‐1‐azulenyl) tetracyanobetadienes and Tris (aryltetracyanobetadiene) s Connected with 1, 3, 5‐Tri (1‐azulenyl) benzene Core

T Shoji, A Maruyama, M Tanaka, D Nagai… - …, 2016 - Wiley Online Library
Tris[(3‐phenyl‐1‐azulenyl)tetracyanobutadiene]s and tris(aryltetracyanobutadiene)s connected
to a 1,3,5‐tri(1‐azulenyl)benzene core (tris‐AzTCBDs) have been prepared by the Pd‐…

An in vivo mechanism for the reduced peripheral neurotoxicity of NK105: a paclitaxel-incorporating polymeric micellar nanoparticle formulation

…, R Goda, H Hayashi, H Mashiba, D Nagai… - International journal …, 2017 - Taylor & Francis
In our previous rodent studies, the paclitaxel (PTX)-incorporating polymeric micellar nanoparticle
formulation NK105 had showed significantly stronger antitumor effects and reduced …

Utility of human hepatocyte spheroids for evaluation of hepatotoxicity

…, K Ohta, T Ohkura, H Arakawa, D Nagai - Fundamental …, 2015 - jstage.jst.go.jp
Drug-induced hepatotoxicity is a common reason for discontinuing the development of
candidate clinical drugs. In the present study, we investigated the utility of three-dimensionally …

Antimyeloma activity of NK012, a micelle‐forming macromolecular prodrug of SN‐38, in an orthotopic model

…, E Ichimura, K Ebara, D Nagai… - … journal of cancer, 2014 - Wiley Online Library
NK012 is a micelle‐forming macromolecular prodrug of 7‐ethyl‐10‐hydroxy camptothecin (SN‐38),
an active metabolite of irinotecan. It is accumulated and retained in tumor tissues …

[PDF][PDF] Synthesis and Electrochemical Properties of Azulene-Substituted Tetracyanobutadiene and Dicyanoquinodimethane Chromophores Connected with …

T Shoji, M Maruyama, A Maruyama, D Nagai… - …, 2017 - soar-ir.repo.nii.ac.jp
Azulene-substituted tetracyanobutadienes (AzTCBDs) and dicyanoquinodimethanes (AzDCNQs)
connected with naphthalene cores were prepared by the reaction of 1-azulenylalkynes …