2-Aminothiazole (1) was discovered as a novel Src family kinase inhibitor template through
screening of our internal compound collection. Optimization through successive structure−…

The Initial rolling Interaction of leukocytes with the blood vessel wall during leukocyte trafficking
has been postulated to rely on members of the selectin family of adhesion molecules. …

Objective The transcription of several cytokines, cell adhesion molecules, and enzymes involved
in the inflammatory and destructive mechanisms of rheumatoid arthritis is dependent on …

The recently described IL-1R accessory protein (IL-1R AcP) interacts with IL-1β and the IL-1
type-IR (IL-1RI), but an essential requirement for IL-1R AcP in IL-1 signaling in vitro has not …

Collagen‐induced arthritis (CIA) is an animal model for rheumatoid arthritis. The disease is
elicited by immunization of genetically susceptible DBA/1 mice with type II collagen, resulting …

Nonreceptor protein tyrosine kinases including Lck, ZAP-70, and Itk play essential roles in T-cell
receptor (TCR) signaling. Gene knockout studies have revealed that mice lacking these …

A novel structural class of p38 mitogen-activated protein (MAP) kinase inhibitors consisting
of substituted 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazines has been discovered. An initial …

RORγt is an important nuclear receptor that regulates the production of several pro-inflammatory
cytokines such as IL-17 and IL-22. As a result, RORγt has been identified as a potential …

A new phenyl (3-phenylpyrrolidin-3-yl)sulfone series of RORγt inverse agonists was discovered
utilizing the binding conformation of previously reported bicyclic sulfonamide 1. Through …

The discovery and characterization of 7k (BMS-582949), a highly selective p38α MAP kinase
inhibitor that is currently in phase II clinical trials for the treatment of rheumatoid arthritis, is …