Objective To determine whether there are gender‐specific differences in the pharmacokinetics
and pharmacodynamics of metoprolol enantiomers. Methods Twenty normal volunteers (…

OBJECTIVE: To review the role of homocysteine as a risk factor in the pathogenesis of
atherosclerosis and to provide recommendations for the treatment of hyperhomocysteinemia. …

Objective Our objective was to compare simvastatin with the validated probe midazolam in
the assessment of cytochrome P450 (CYP) 3A activity. Methods This study used an open‐…

Background Increased consumption of the lipogenic sugar fructose promotes the current
epidemic of metabolic disease. Ketohexokinase (KHK) catalyzes the first committed step in …

Electrocardiographic (ECG) recordings from 3 placebo‐controlled thorough QT healthy
volunteer studies were used to compare QT intervals obtained by manual measurement with …

Objective To investigate the effect of steady‐state fluconazole administration on the disposition
of eprosartan, losartan, and E‐3174. Methods Sixteen healthy male subjects received …

PF ‐04991532 ((S)‐6‐(3‐Cyclopentyl‐2‐(4‐(trifluoromethyl)‐1H‐imidazol‐1‐yl) propanamido)
nicotinic acid) is a glucokinase activator designed to achieve hepato‐selectivity via …

Aims To conduct a dose‐response assessment of the efficacy and safety of the glucagon
receptor antagonist PF‐06291874 in adults with type 2 diabetes (T2DM) using stable doses of …

Aims The glucagon receptor antagonist PF-06291874 has demonstrated robust glucose
reductions in subjects with type 2 diabetes mellitus (T2DM) on background metformin. This …

This study was conducted to determine whether gender differences exist in adrenergic
receptor sensitivity and baroreflex response. Adrenergic receptor sensitivity was assessed by …