2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (9) was designed as a conformationally
constrained analog of glutamic acid. For 9, the key torsion angles (τ 1 and τ 2 ) which …

LY354740 is a conformationally constrained analog of glutamate which is a potent agonist
for group II cAMP coupled metabotropic glutamate receptors (mGluRs). The discovery of this …

In this paper we describe the synthesis of a series of α-substituted analogues of the potent
and selective group II metabotropic glutamate receptor (mGluR) agonist (1S,1‘S,2‘S)-…

Three different behavioral measures were used to assess the effects of abrupt cessation of
chronic nicotine treatment. Nicotine (0, 3, or 6 mg/kg per day) was continuously administered …

Urotensin II (UII) is a vasomodulatory peptide that was not predicted to elicit CNS activity.
However, because we have recently shown that the urotensin II receptor (UII-R) is selectively …

Withdrawal from the chronic administration of nicotine has previously been shown to lead to
an enhanced auditory startle response in rats. In order to explore the neuropharmacology …

The side-effect profile of quinolone antibiotics in man includes CNS disturbances such as
dizziness, insomnia and convulsions. Although it has been suggested that the proconvulsive …

The activity of LY288513, an investigational cholecystokinin (CCK) B antagonist, was evaluated
in a wide range of pharmacological tests in mice and rats. The anxiolytic benzodiazepine…

Dapsone is a potent anti-inflammatory and antibacterial agent that has been used extensively
in the oral treatment of leprosy and dermatitis herpetiformis. This study compared the …

The functional role of metabotropic glutamate receptor (mGluR) activation was investigated
following intracerebral administration of 1S,3R-ACPD in mice. Injections of 1S,3R-ACPD (50–…