Protein disaggregation mediated by heat-shock protein Hspl04
DA Parsell, AS Kowal, MA Singer, S Lindquist - Nature, 1994 - nature.com
THE heat-inducible members of the HsplOO (or Clp) family of proteins share a common function
in helping organisms to survive extreme stress, but the basic mechanism through which …
in helping organisms to survive extreme stress, but the basic mechanism through which …
The role of heat-shock proteins in thermotolerance
DA Parsell, J Taulien… - … Transactions of the …, 1993 - royalsocietypublishing.org
The role of heat-shock proteins (hsps) in thermotolerance was examined in the budding yeast
Saccharomyces cerevisiae and in the fruit fly Drosophila melanogaster. In yeast cells, the …
Saccharomyces cerevisiae and in the fruit fly Drosophila melanogaster. In yeast cells, the …
[HTML][HTML] Saccharomyces cerevisiae Hsp104 protein. Purification and characterization of ATP-induced structural changes.
DA Parsell, AS Kowal, S Lindquist - Journal of Biological Chemistry, 1994 - Elsevier
Heat-shock proteins (hsps) function in a variety of ways to help cells and organisms cope
with environmental changes. One class of hsps, the Hsp100 proteins, is especially important …
with environmental changes. One class of hsps, the Hsp100 proteins, is especially important …
Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women
…, SE Rocco, KM Sutherland, DA Parsell… - Human …, 1999 - academic.oup.com
Although the role of the reproductive hormone, relaxin, in rodents is well documented, its
potential contribution to human reproduction is less well defined. In this study, we examine the …
potential contribution to human reproduction is less well defined. In this study, we examine the …
Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.
DA Parsell, RT Sauer - Genes & development, 1989 - genesdev.cshlp.org
To test the idea that unfolded protein might act as an intracellular signal for induction of the
heat shock response in Escherichia coli, we examined the synthesis of several heat shock …
heat shock response in Escherichia coli, we examined the synthesis of several heat shock …
[HTML][HTML] The ATPase activity of Hsp104, effects of environmental conditions and mutations
EC Schirmer, C Queitsch, AS Kowal, DA Parsell… - Journal of Biological …, 1998 - ASBMB
Hsp104 is crucial for stress tolerance inSaccharomyces cerevisiae, and both of its
nucleotide-binding domains (NBD1 and NBD2) are required. Here, we characterize the ATPase …
nucleotide-binding domains (NBD1 and NBD2) are required. Here, we characterize the ATPase …
Long-term safety and efficacy of veverimer in patients with metabolic acidosis in chronic kidney disease: a multicentre, randomised, blinded, placebo-controlled, 40 …
Background Metabolic acidosis, a complication of chronic kidney disease, causes protein
catabolism and bone demineralisation and is associated with adverse kidney outcomes and …
catabolism and bone demineralisation and is associated with adverse kidney outcomes and …
Veverimer versus placebo in patients with metabolic acidosis associated with chronic kidney disease: a multicentre, randomised, double-blind, controlled, phase 3 trial
Background Patients with advanced chronic kidney disease lose the capacity to fully excrete
endogenous acid, resulting in chronic metabolic acidosis that increases the risk of disease …
endogenous acid, resulting in chronic metabolic acidosis that increases the risk of disease …
[PDF][PDF] Heat-shock proteins Hsp104 and Hsp70 reactivate mRNA splicing after heat inactivation
JL Vogel, DA Parsell, S Lindquist - Current Biology, 1995 - cell.com
Background: The heat-shock protein Hsp104 plays a crucial role in the survival of cells
exposed to high temperatures and other severe stresses, but its specific functions and the …
exposed to high temperatures and other severe stresses, but its specific functions and the …
Betamethasone valerate foam 0.12%: a novel vehicle with enhanced delivery and efficacy
TJ Franz, DA Parsell, RM Halualani… - International journal …, 1999 - Wiley Online Library
Background: A new topical formulation of betamethasone valerate (BMV) with enhanced
dermal penetration has been developed. Objective: These studies were designed to evaluate: (…
dermal penetration has been developed. Objective: These studies were designed to evaluate: (…