User profiles for Deepak K. Bhatt
 | Deepak Kumar BhattPostdoc, Biotech research and Innovation Center (BRIC), Copenhagen Verified email at bric.ku.dk Cited by 1571 |
Age‐and genotype‐dependent variability in the protein abundance and activity of six major uridine diphosphate‐glucuronosyltransferases in human liver
DK Bhatt, A Mehrotra, A Gaedigk… - Clinical …, 2019 - Wiley Online Library
The ontogeny of hepatic uridine diphosphate‐glucuronosyltransferases (UGTs) was investigated
by determining their protein abundance in human liver microsomes isolated from 136 …
by determining their protein abundance in human liver microsomes isolated from 136 …
Abundance of phase 1 and 2 drug-metabolizing enzymes in alcoholic and hepatitis C cirrhotic livers: a quantitative targeted proteomics study
To predict the impact of liver cirrhosis on hepatic drug clearance using physiologically based
pharmacokinetic (PBPK) modeling, we compared the protein abundance of various phase …
pharmacokinetic (PBPK) modeling, we compared the protein abundance of various phase …
Age-dependent absolute abundance of hepatic carboxylesterases (CES1 and CES2) by LC-MS/MS proteomics: application to PBPK modeling of oseltamivir in vivo …
…, A Mehrotra, RE Pearce, A Gaedigk, DK Bhatt… - Drug Metabolism and …, 2017 - ASPET
The age-dependent absolute protein abundance of carboxylesterase (CES) 1 and CES2 in
human liver was investigated and applied to predict infant pharmacokinetics (PK) of …
human liver was investigated and applied to predict infant pharmacokinetics (PK) of …
Critical issues and optimized practices in quantification of protein abundance level to determine interindividual variability in DMET proteins by LC‐MS/MS proteomics
Protein quantification data on drug metabolizing enzymes and transporters (collectively referred
as DMET proteins) in human tissues are useful in predicting interindividual variability in …
as DMET proteins) in human tissues are useful in predicting interindividual variability in …
PBDEs altered gut microbiome and bile acid homeostasis in male C57BL/6 mice
Polybrominated diphenyl ethers (PBDEs) are persistent environmental contaminants with
well characterized toxicities in host organs. Gut microbiome is increasingly recognized as an …
well characterized toxicities in host organs. Gut microbiome is increasingly recognized as an …
Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation
R Ramachandran, DK Bhatt, KB Ploug… - …, 2014 - journals.sagepub.com
Background and aim Infusion of glyceryltrinitrate (GTN), a nitric oxide (NO) donor, in awake,
freely moving rats closely mimics a universally accepted human model of migraine and …
freely moving rats closely mimics a universally accepted human model of migraine and …
Ontogeny of hepatic sulfotransferases and prediction of age-dependent fractional contribution of sulfation in acetaminophen metabolism
Cytosolic sulfotransferases (SULTs), including SULT1A, SULT1B, SULT1E, and SULT2A
isoforms, play noteworthy roles in xenobiotic and endobiotic metabolism. We quantified the …
isoforms, play noteworthy roles in xenobiotic and endobiotic metabolism. We quantified the …
Hepatic abundance and activity of androgen-and drug-metabolizing enzyme UGT2B17 are associated with genotype, age, and sex
The major objective of this study was to investigate the association of genetic and
nongenetic factors with variability in protein abundance and in vitro activity of the androgen-…
nongenetic factors with variability in protein abundance and in vitro activity of the androgen-…
Integrative molecular characterisation of gallbladder cancer reveals micro-environment-associated subtypes
Background & Aims Gallbladder cancer (GBC) is the most common type of biliary tract
cancer, but the molecular mechanisms involved in gallbladder carcinogenesis remain poorly …
cancer, but the molecular mechanisms involved in gallbladder carcinogenesis remain poorly …
Genetic and nongenetic factors associated with protein abundance of flavin-containing monooxygenase 3 in human liver
Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of
nucleophilic heteroatom (eg, N or S)-containing xenobiotics (eg, amphetamine, sulindac, …
nucleophilic heteroatom (eg, N or S)-containing xenobiotics (eg, amphetamine, sulindac, …