Although they have several important limitations primary human hepatocytes still represent
the in vitro gold standard model for xenobiotic metabolism and toxicity studies. The large use …

Among numerous established human hepatoma cell lines, none has been shown susceptible
to hepatitis B virus (HBV) infection. We describe here a cell line, called HepaRG, which …

Most human hepatocyte cell lines lack a substantial set of liver-specific functions, especially
major cytochrome P450 (P450)-related enzyme activities, making them unrepresentative of …

When adult rat hepatocytes were co-cultured with another liver epithelial cell type in a medium
supplemented or not with fetal calf serum (FCS), it was found that 1. 1. They survived for …

Hepatic tumors, exhibiting mature hepatocytes and undifferentiated cells merging with
cholangiocyte and hepatocyte phenotypes, are frequently described. The mechanisms by which …

In this study, activation of the mitogen-activated protein kinase kinase (MEK)/extracellular
signal-regulated kinase (ERK) signalling pathway was analyzed in proliferating rat …

Many solid malignant tumors arise on a background of inflamed and/or fibrotic tissues,
features that are found in more than 80% hepatocellular carcinomas (HCC). Activated hepatic …

Functional expression of both sinusoidal and canalicular hepatic drug transporters was
investigated in the highly differentiated human hepatoma HepaRG cell line and also, for …

The human hepatoma HepaRG cells are able to differentiate in vitro into hepatocyte-like cells
and to express various liver-specific functions, including the major cytochromes P450. This …

Several hepatocyte mitogens have been identified, but the signals triggering the G 0 /G 1
transition and cell cycle progression of hepatocytes remain unknown. Using hepatocyte …