User profiles for Dominic P. Williams

Dr Dominic Williams

Astrazeneca
Verified email at liv.ac.uk
Cited by 14765

The role of metabolic activation in drug-induced hepatotoxicity

…, JL Maggs, M Pirmohamed, DP Williams - Annu. Rev …, 2005 - annualreviews.org
▪ Abstract The importance of reactive metabolites in the pathogenesis of drug-induced
toxicity has been a focus of research interest since pioneering investigations in the 1950s …

Managing the challenge of chemically reactive metabolites in drug development

…, DJ Tweedie, N Vermeulen, DP Williams… - Nature Reviews Drug …, 2011 - nature.com
The normal metabolism of drugs can generate metabolites that have intrinsic chemical reactivity
towards cellular molecules, and therefore have the potential to alter biological function …

RETRACTED: molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen …

DJ Antoine, RE Jenkins, JW Dear, DP Williams… - 2012 - Elsevier
BACKGROUND & AIMS: Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1)
represent circulating indicators of necrosis during acetaminophen (APAP) …

Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study

…, A Baze, AJ Foster, DP Williams… - Toxicological …, 2018 - academic.oup.com
Primary human hepatocytes (PHHs) are commonly used for in vitro studies of drug-induced
liver injury. However, when cultured as 2D monolayers, PHH lose crucial hepatic functions …

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

DJ Antoine, DP Williams, A Kipar… - Toxicological …, 2009 - academic.oup.com
Drug-induced hepatotoxicity represents a major clinical problem and an impediment to new
medicine development. Serum biomarkers hold the potential to provide information about …

[PDF][PDF] Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice

…, R Elsby, LE Randle, YN Clement, DP Williams… - …, 2004 - Wiley Online Library
The transcription factor NF‐E2‐related factor 2 (Nrf2) plays an essential role in the
mammalian response to chemical and oxidative stress through induction of hepatic phase II …

Acyl glucuronides: the good, the bad and the ugly

…, TG Hammond, C Lambert, DP Williams… - … & drug disposition, 2010 - Wiley Online Library
Acyl glucuronidation is the major metabolic conjugation reaction of most carboxylic acid
drugs in mammals. The physiological consequences of this biotransformation have been …

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

…, J Snoeys, B van de Water, DP Williams… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological
process that cannot yet be recapitulated in a single in vitro model. Current preclinical …

Synergistic interactions between commonly used food additives in a developmental neurotoxicity test

K Lau, WG McLean, DP Williams… - Toxicological …, 2006 - academic.oup.com
Exposure to non-nutritional food additives during the critical development window has been
implicated in the induction and severity of behavioral disorders such as attention deficit …

Characterisation of the toxic metabolite (s) of naphthalene

AS Wilson, CD Davis, DP Williams, AR Buckpitt… - Toxicology, 1996 - Elsevier
The toxicity of naphthalene and its metabolites has been investigated in vitro. Both
naphthalene and its metabolite 1-naphthol were bioactivated by human hepatic microsomes to …