The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to
environmental stimuli. It was recognized historically for its role in toxicology but, in recent …

Major depressive disorder (MDD) is a heterogeneous disease. Efforts to identify biomarkers
for sub-classifying MDD and antidepressant therapy by genome-wide association studies (…

The mechanisms by which DNA alleles contribute to disease risk, drug response, and other
human phenotypes are highly context-specific, varying across cell types and different …

The hypothalamus is a region of the brain that plays an important role in regulating body
functions and behaviors. There is a growing interest in human pluripotent stem cells (hPSCs) for …

Greater than 90% of significant genome-wide association study (GWAS) single-nucleotide
polymorphisms (SNPs) are in noncoding regions of the genome, but only 25.6% are known …

CYP2C9 and CYP2C19 are highly polymorphic pharmacogenes; however, clinically
actionable genetic variability in drug metabolism due to these genes has been limited to a few …

Major depressive disorder (MDD) is a severe illness that afflicts about 16.6% of people over
their lifetime. MDD is highly correlated with suicidality, and often first presents in adolescence…

Background The discovery that somatic cells can be reprogrammed to induced pluripotent
stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug …

Millions of patients suffer from major depressive disorder (MDD), but many do not respond
to selective serotonin reuptake inhibitor (SSRI) therapy. We used a pharmacometabolomics-…

Introduction The initial decades of the twenty-first century have witnessed striking technical
advances that have made it possible to detect, identify and quantitatively measure large …