A novel angiotensin-converting enzyme–related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

M Donoghue, F Hsieh, E Baronas, K Godbout… - Circulation …, 2000 - Am Heart Assoc
ACE2, the first known human homologue of angiotensin-converting enzyme (ACE), was
identified from 5′ sequencing of a human heart failure ventricle cDNA library. ACE2 has an …

[HTML][HTML] Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

…, J Tang, K Godbout, T Parsons, E Baronas… - Journal of Biological …, 2002 - ASBMB
Human angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a zinc
metalloprotease whose closest homolog is angiotensin I-converting enzyme. To begin to elucidate …

Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites

…, J Labutti, I Parsons, D Nix, E Baronas… - Drug Metabolism and …, 2005 - ASPET
Bortezomib [N-(2,3-pyrazine)carbonyl-l-phenylalanine-l-leucine boronic acid] is a potent first-in-class
dipeptidyl boronic acid proteasome inhibitor that was approved in May 2003 in the …

Biomarkers to monitor drug-induced phospholipidosis

ET Baronas, JW Lee, C Alden, FY Hsieh - Toxicology and applied …, 2007 - Elsevier
Di-docosahexaenoyl (C22:6)-bis(monoacylglycerol) phosphate (BMP) was identified as a
promising phospholipidosis (PL) biomarker in rats treated with either amiodarone, gentamicin, …

[PDF][PDF] UltraRapid communication

M Donoghue, F Hsieh, E Baronas, K Godbout… - Circulation …, 2000 - academia.edu
ACE2, the first known human homologue of angiotensin-converting enzyme (ACE), was
identified from 5 sequencing of a human heart failure ventricle cDNA library. ACE2 has an …

A novel nanospray capillary zone electrophoresis/mass spectrometry interface

F Hsieh, E Baronas, C Muir… - Rapid communications in …, 1999 - Wiley Online Library
The high resolution of capillary zone electrophoresis/mass spectrometry (CZE/MS) offers a
promising technique to characterize biomolecules in pharmaceutical and biotechnology …

[PDF][PDF] FUNDAMENTALS OF OLIGONUCLEOTIDE REACTIONS IN MASS SPECTROMETRY

MM SPECTROMETERS - core.ac.uk
Tallahassee, FL; 2Mosaique Diagnostics and Therapeutics, Hannover, Germany WOCpm
04:20 The Top-down Characterization of Nucleic Page 1 52nd ASMS Conference on Mass …

Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation

…, AR Thorner, S Leppanen, J Baronas… - Blood …, 2019 - ashpublications.org
Immune evasion is a hallmark of cancer and a central mechanism underlying acquired
resistance to immune therapy. In allogeneic hematopoietic cell transplantation (alloHCT), late …

Preclinical evaluation of the recombinant dendritic cell growth factor CDX-301 (Flt3L), and AST-008, a TLR9 agonist SNA

…, EM Forsberg, EQ Do, JM Boyer, AR Baronas… - Cancer Research, 2019 - AACR
Recent studies have highlighted the critical role of CD103 + /CD141 + dendritic cells (DCs) in
antitumor immunity. CDX-301 is a soluble, recombinant human FLT3 ligand (Flt3L). Flt3L is …

Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy

…, EM Forsberg, J Weidlick, AR Baronas… - Cancer Immunology …, 2019 - Springer
Limitations of immunotherapy include poorly functioning events early in the immune
response cycle, such as efficient antigen presentation and T cell priming. CD40 signaling in …