User profiles for F Oesch
 | Franz OeschJohannes Gutenberg-University, Mainz, Germany Verified email at uni-mainz.de Cited by 32436 |
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds
F Oesch - Xenobiotica, 1973 - Taylor & Francis
Several aromatic and olefinic compounds are converted to intermediate arene and alkene
oxides by mammalian mono-oxygenases. Intermediate arene oxides rearrange non-…
oxides by mammalian mono-oxygenases. Intermediate arene oxides rearrange non-…
Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations—many questions, some …
…, MD Kapp, M Schulz, K Wiench, F Oesch - … Research/Reviews in …, 2009 - Elsevier
Nanomaterials display novel properties to which most toxicologists have not consciously
been exposed before the advent of their practical use. The same properties, small size and …
been exposed before the advent of their practical use. The same properties, small size and …
Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction
…, K Biefang, M Gerl, T Böttger, F Oesch - Drug metabolism …, 2000 - Taylor & Francis
The use of primary hepatocytes is now well established for both studies of drug metabolism
and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for …
and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for …
Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron
…, D Steinbach, R Häfer, T Stamminger, F Oesch… - Free Radical Biology …, 2004 - Elsevier
Iron(II) heme-mediated activation of the peroxide bond of artemisinins is thought to generate
the radical oxygen species responsible for their antimalarial activity. We analyzed the role of …
the radical oxygen species responsible for their antimalarial activity. We analyzed the role of …
Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than …
…, K Schlink, C Dietrich, D Faust, B Epe, F Oesch - …, 2003 - academic.oup.com
Co-exposure to cadmium, cobalt, lead and other heavy metals occurs in many occupational
settings, such as pigment and batteries production, galvanization and recycling of electric …
settings, such as pigment and batteries production, galvanization and recycling of electric …
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility
It has become clear that several polymorphisms of human drug-metabolizing enzymes
influence an individual’s susceptibility for chemical carcinogenesis. This review gives an …
influence an individual’s susceptibility for chemical carcinogenesis. This review gives an …
New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard …
…, T Koose, HJ Burger, J Maas, F Oesch - Drug metabolism …, 2003 - Taylor & Francis
Primary hepatocytes represent a well-accepted in vitro cell culture system for studies of drug
metabolism, enzyme induction, transplantation, viral hepatitis, and hepatocyte regeneration. …
metabolism, enzyme induction, transplantation, viral hepatitis, and hepatocyte regeneration. …
Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma
Peptides derived from melanocyte differentiation antigens have been identified as targets for
MHC class I‐restricted cytolytic T lymphocytes (CTLs) in human melanoma. Regression of …
MHC class I‐restricted cytolytic T lymphocytes (CTLs) in human melanoma. Regression of …
Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic‐T‐cell responses: Evidence for immunoselection of antigen‐loss …
Antigenic peptides derived from differentiation antigens of the melanocyte lineage were
recently identified in human melanomas as targets for MHC‐restricted cytotoxic T lymphocytes (…
recently identified in human melanomas as targets for MHC‐restricted cytotoxic T lymphocytes (…