Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts
Previous studies have shown that in a cell-free system, metallothionein (MT) releases zinc
when the environment becomes oxidized and the released zinc is transferred to a zinc-…
when the environment becomes oxidized and the released zinc is transferred to a zinc-…
Structural insights into the pharmacophore of vinca domain inhibitors of microtubules
Y Wang, FW Benz, Y Wu, Q Wang, Y Chen, X Chen… - Molecular …, 2016 - ASPET
Antibody-drug conjugates (ADCs) have achieved great success in cancer therapy in recent
years. Some peptidyl microtubule inhibitors consisting of natural and unnatural amino acids, …
years. Some peptidyl microtubule inhibitors consisting of natural and unnatural amino acids, …
[HTML][HTML] Metallothionein disulfides are present in metallothionein-overexpressing transgenic mouse heart and increase under conditions of oxidative stress
W Feng, FW Benz, J Cai, WM Pierce… - Journal of Biological …, 2006 - ASBMB
Metallothionein (MT) releases zinc under oxidative stress conditions in cultured cells. The
change in the MT molecule after zinc release in vivo is unknown although in vitro studies have …
change in the MT molecule after zinc release in vivo is unknown although in vitro studies have …
Biological markers of acute acrylonitrile intoxication in rats as a function of dose and time
FW Benz, DE Nerland, D Corbett, J Li - Toxicological Sciences, 1997 - academic.oup.com
Three markers of acute acrylonitrile (AN) intoxication, namely, tissue glutathione (GSH), tissue
cyanide (CN), and covalent binding to tissue protein, were studied as a function of dose …
cyanide (CN), and covalent binding to tissue protein, were studied as a function of dose …
Fourier transform proton NMR spectroscopy in aqueous solution
FW Benz, J Feeney, GCK Roberts - Journal of Magnetic Resonance (1969), 1972 - Elsevier
Recording Fourier transform proton NMR spectra in dilute aqueous solution, where the
residual HDO resonance may be 2–3 orders of magnitude greater than the absorptions of the …
residual HDO resonance may be 2–3 orders of magnitude greater than the absorptions of the …
[HTML][HTML] Redox states of protein cysteines in pathways of protein turnover and cytoskeleton dynamics are changed with aging and reversed by Slc7a11 restoration in …
…, JD Ritzenthaler, M Li, AE Gaweda, FW Benz… - … Medicine and Cellular …, 2020 - hindawi.com
Slc7a11 is the key component of system X c - , an antiporter that imports cystine (CySS) and
exports glutamate. It plays an important role in cellular defense against oxidative stress …
exports glutamate. It plays an important role in cellular defense against oxidative stress …
Acrylonitrile irreversibly inactivates glyceraldehyde-3-phosphate dehydrogenase by alkylating the catalytically active cysteine 149
EC Campian, J Cai, FW Benz - Chemico-biological interactions, 2002 - Elsevier
Acrylonitrile (AN) is a vinyl monomer used in the production of synthetic fibers, rubber and
plastics. AN is acutely toxic but its mechanism of toxicity remains to be established. AN is …
plastics. AN is acutely toxic but its mechanism of toxicity remains to be established. AN is …
Acute acrylonitrile toxicity: studies on the mechanism of the antidotal effect of D-and L-cysteine and their N-acetyl derivatives in the rat
FW Benz, DE Nerland, WM Pierce, C Babiuk - Toxicology and applied …, 1990 - Elsevier
Thiol-containing antibotes for acute acrylonitrile (AN) toxicity may exert their action by chemically
reacting with AN, by replacing critical sulfhydryl groups cyanoethylated by AN, and by …
reacting with AN, by replacing critical sulfhydryl groups cyanoethylated by AN, and by …
Covalent binding of acrylonitrile to specific rat liver glutathione S-transferases in vivo
…, J Cai, WM Pierce, FW Benz - Chemical research in …, 2001 - ACS Publications
Acrylonitrile (AN) is an industrial vinyl monomer that is acutely toxic. When administered to
rats, AN covalently binds to tissue proteins in a dose-dependent but nonlinear manner [Benz, …
rats, AN covalently binds to tissue proteins in a dose-dependent but nonlinear manner [Benz, …
Effects of cysteine isomers and derivatives on acute acrylonitrile toxicity
DE Nerland, FW Benz, C Babiuk - Drug Metabolism Reviews, 1989 - Taylor & Francis
The aliphatic nitriles are a class of commercially important organic compounds which have
the general structure R-CN. The aliphatic nitriles are
the general structure R-CN. The aliphatic nitriles are