Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded
enzymes required for replication and therefore a rational target for chemotherapeutic …

Peptides derived from the heptad repeat 2 (HR2) region of the HIV fusogenic protein gp41
are potent inhibitors of viral infection, and one of them, enfuvirtide, is used for the treatment of …

A novel strategy to minimize phospholipids-based matrix effects in bioanalytical LC–MS/MS
assays was evaluated. The phospholipids-based matrix effect was investigated with a …

Human immunodeficiency virus type-1 (HIV-1) integrase, one of the three constitutive viral
enzymes required for replication, is a rational target for chemotherapeutic intervention in the …

Infections caused by hepatitis C virus (HCV) are a significant world health problem for which
novel therapies are in urgent demand. Compounds that block replication of subgenomic …

Obesity is one of the major risk factors for type 2 diabetes, and the development of agents,
that can simultaneously achieve glucose control and weight loss, is being actively pursued. …

The NS2-NS3 region of the hepatitis C virus polyprotein encodes a proteolytic activity that is
required for processing of the NS2/3 junction. Membrane association of NS2 and the …

Bacteria adapt their pattern of gene expression in response to a variety of external cues,
including fluctuations in population density. This type of bacterial cell‐to‐cell communication is …

The human immunodeficiency virus type-1 (HIV-1) encodes three enzymes essential for viral
replication: a reverse transcriptase, a protease, and an integrase. The latter is responsible …

Infections caused by the hepatitis C virus (HCV) are a significant world health problem for
which novel therapies are in urgent demand. The NS5B polymerase of HCV is responsible for …