Glucuronidation and the UDP-glucuronosyltransferases in health and disease
…, PA Gregory, Y Ishii, AJ Hansen, FK Kessler… - Drug metabolism and …, 2004 - ASPET
This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …
[HTML][HTML] Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation
NE Kaminski, ME Abood, FK Kessler… - Molecular …, 1992 - ncbi.nlm.nih.gov
Extensive behavioral and biochemical characterization of cannabinoid-mediated effects on
the central nervous system has revealed at least three lines of evidence supporting the role …
the central nervous system has revealed at least three lines of evidence supporting the role …
Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene
…, JK Ritter, DJ Auyeung, FK Kessler… - Pharmacogenetics …, 2000 - journals.lww.com
One of the most important mechanisms involved in host defense against xenobiotic
chemicals and endogenous toxins is the glucuronidation catalysed by UDP-glucuronosyltransferase …
chemicals and endogenous toxins is the glucuronidation catalysed by UDP-glucuronosyltransferase …
[PDF][PDF] Expression and inducibility of the human bilirubin UDP‐glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: Evidence for both genetic …
JK Ritter, FK Kessler, MT Thompson, AD Grove… - …, 1999 - Wiley Online Library
In Crigler‐Najjar type II patients and, recently, in Crigler‐Najjar type I patients treated with
human hepatocyte cell therapy, phenobarbital has been used for reducing the serum bilirubin …
human hepatocyte cell therapy, phenobarbital has been used for reducing the serum bilirubin …
Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein …
…, WS Koh, KH Yang, M Lee, FK Kessler - Biochemical …, 1994 - Elsevier
Cannabinoid compounds, including the major psychoative component of marihuana, Δ 9 -tetrahydrocannabinol
(Δ 9 -THC), have been widely established as being inhibitory on a broad …
(Δ 9 -THC), have been widely established as being inhibitory on a broad …
An investigation of human and rat liver microsomal mycophenolic acid glucuronidation: evidence for a principal role of UGT1A enzymes and species differences in …
KK Miles, ST Stern, PC Smith, FK Kessler, S Ali… - Drug metabolism and …, 2005 - ASPET
Mycophenolic acid (MPA; 1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzylfuranyl)-4-methyl-4-hexenoate),
the active metabolite of the immunosuppressant prodrug, …
the active metabolite of the immunosuppressant prodrug, …
Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway
DJ Auyeung, FK Kessler, JK Ritter - Molecular pharmacology, 2003 - ASPET
The utility of oltipraz as a cancer chemopreventive agent is thought to depend on the
induction of enzymes involved in phase 2 xenobiotic detoxification. Although studies of some …
induction of enzymes involved in phase 2 xenobiotic detoxification. Although studies of some …
Absolute quantification of human uridine-diphosphate glucuronosyl transferase (UGT) enzyme isoforms 1A1 and 1A6 by tandem LC-MS
…, DE Harbourt, SH Maleki, FK Kessler… - Drug metabolism …, 2008 - ingentaconnect.com
UGT enzymes catalyze the formation of glucuronic acid conjugates. Specifically selected
representative stable isotope (C13, N15) labeled peptide internal standards of each enzyme …
representative stable isotope (C13, N15) labeled peptide internal standards of each enzyme …
Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases
FK Kessler, MR Kessler, DJ Auyeung… - Drug metabolism and …, 2002 - ASPET
Gunn rats glucuronidate acetaminophen (APAP) at reduced rates and show increased
susceptibility to APAP-induced hepatotoxicity. This defect is presumed to involve UDP-…
susceptibility to APAP-induced hepatotoxicity. This defect is presumed to involve UDP-…
[HTML][HTML] Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo (a) pyrene-7, 8-dihydrodiol
AD Grove, FK Kessler, RP Metz, JK Ritter - Journal of Biological Chemistry, 1997 - ASBMB
Previous work has shown that polycyclic aromatic hydrocarbons and oltipraz both induce an
unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a)pyrene-7,8-…
unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a)pyrene-7,8-…