Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients

V Soumelis, I Scott, F Gheyas… - Blood, The Journal …, 2001 - ashpublications.org
Natural interferon-α producing cells (IPCs) are a newly characterized blood cell type, which
is the major source of type I interferons in antiviral innate immune responses. The …

Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

…, Q Wu, L Wang, T McClanahan, WR Bishop, F Gheyas… - Oncogene, 2003 - nature.com
The temporal gene expression profile during the entire process of apoptosis and cell cycle
progression in response to p53 in human ovarian cancer cells was explored with cDNA …

[HTML][HTML] Human members of the eukaryotic protein kinase family

M Kostich, J English, V Madison, F Gheyas, L Wang… - Genome Biology, 2002 - Springer
Background Eukaryotic protein kinases (EPKs) constitute one of the largest recognized
protein families represented in the human genome. EPKs, which are similar to each other in …

Composite method to quantify powder flow as a screening method in early tablet or capsule formulation development

MK Taylor, J Ginsburg, AJ Hickey, F Gheyas - AAPS PharmSciTech, 2000 - Springer
The flow properties of typial tablet and capsule formulation excipients, active compounds,
and representative formulation blends were tested with current and novel flow measurement …

[HTML][HTML] Microarray profile of differentially expressed genes in a monkey model of allergic asthma

J Zou, S Young, F Zhu, F Gheyas, S Skeans, Y Wan… - Genome biology, 2002 - Springer
Background Inhalation of Ascaris suum antigen by allergic monkeys causes an immediate
bronchoconstriction and delayed allergic reaction, including a pulmonary inflammatory …

Population pharmacokinetics of vericiguat in patients with heart failure with reduced ejection fraction: an integrated analysis

…, M Meyer, C Becker, F Gheyas - Clinical …, 2022 - Wiley Online Library
Vericiguat, a novel stimulator of soluble guanylate cyclase (sGC), is indicated for the treatment
of patients following a hospitalization for heart failure or need for outpatient intravenous …

Population pharmacokinetic/pharmacodynamic assessment of imipenem/cilastatin/relebactam in patients with hospital‐acquired/ventilator‐associated bacterial …

…, P Kulkarni, W Copalu, F Gheyas… - Clinical and …, 2022 - Wiley Online Library
In the phase III RESTORE‐IMI 2 study (ClinicalTrials.gov: NCT02493764), the combination
antibacterial agent imipenem/cilastatin/relebactam (IMI/REL) demonstrated noninferiority to …

A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson's Disease in Participants With Leucine‐Rich Repeat Kinase 2 Mutation

…, N Hanan, K Lai Yee, F Gheyas… - Clinical …, 2021 - Wiley Online Library
Leucine‐rich repeat kinase 2 (LRRK2) inhibitors are currently in clinical development as
interventions to slow progression of Parkinson’s disease (PD). Understanding the rate of …

Dietary fibre content of thirteen apple cultivars

F Gheyas, SM Blankenship, E Young… - Journal of the …, 1997 - Wiley Online Library
Gheyas F 1994 Dietary ذber in apple fruit as inرuenced by cultivar, rootstock, growing
region, developmental stage and storage. PhD thesis, North Carolina State University, Raleigh, …

Formulation and process considerations for beads containing Carbopol® 974P, NF resin made by extrusion-spheronization

…, MY Chow, GA Hileman, MJ Durrani, F Gheyas… - International Journal of …, 2000 - Elsevier
Preliminary studies revealed that Carbopol® 974P, NF resin could be incorporated into beads
manufactured by extrusion and spheronization, and can slow the release of a highly water …